CitalopraM DiMethylaMinobutanone

Base Information

• Chemical Name: CitalopraM DiMethylaMinobutanone
• CAS No.: 1329745-98-3
• Molecular Formula: C25H33FN2O2
• Molecular Weight: 412.5401232
• Mol file: 1329745-98-3.mol

Synonyms:CitalopraM DiMethylaMinobutanone;4-(DiMethylaMino)-1-[1-[3-(diMethylaMino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuranyl]-1-butanone;Citalopram Dimethylaminobutanone Di-Oxalate (Citalopram Impurity G)

Chemical Property of CitalopraM DiMethylaMinobutanone

Chemical Property:

Purity/Quality:

99%min. ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Citalopram Dimethylaminobutanone is an impurity of Citalopram, Hydrobromide Salt(C505000). Citalopram is an inhibitor of serotonin (5-HT) uptake. Used as an antidepressant. Potent selective serotonin reuptake inhibitor (SSRI).

Technology Process of CitalopraM DiMethylaMinobutanone

There total 10 articles about CitalopraM DiMethylaMinobutanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

C25H35FN2O2 → (R)-4-(dimethylamino)-1-(1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-yl)-1-butanone (1329745-98-3)

Guidance literature:

With Dess-Martin periodane; In ethyl acetate; at 20 ℃;

Reference yield: 50.9%

C25H35FN2O2 → (S)-4-dimethylamino-1-{1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-yl}-1-butanone (1329745-98-3)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; for 4h;

Reference yield:

3-(Dimethylamino)propyl chloride (109-54-6) → (R)-4-(dimethylamino)-1-(1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-yl)-1-butanone (1329745-98-3)

Guidance literature:

Multi-step reaction with 3 steps

1: magnesium; iodine / tetrahydrofuran; ethylene dibromide / Inert atmosphere; Reflux

2: tetrahydrofuran / 20 °C

3: Dess-Martin periodane / ethyl acetate / 20 °C

With iodine; Dess-Martin periodane; magnesium; In tetrahydrofuran; ethyl acetate; ethylene dibromide;

upstream raw materials:

3-(Dimethylamino)propyl chloride

(S)-1-[3-(dimethylamino)propyl]-1-(4-flouorphenyl)-1,3-dihydro-5-isobenzofuran carbonitrile

3-(N,N-dimethylamino)propylmagnesium chloride

C₂₀H₂₂FNO₂

Refernces

• 1、 -. "Preparation method of escitalopram oxalate impurities". . . Retrieved 2017/08/29.