Cefdinir Lactone

Base Information

• Chemical Name: Cefdinir Lactone
• CAS No.: 946573-41-7
• Molecular Formula: C₁₄H₁₃N₅O₅S₂
• Molecular Weight: 395.42
• Mol file: 946573-41-7.mol

Synonyms:Cefdinir Lactone;(αZ)-2-AMino-α-(hydroxyiMino)-N-[(5aR,6R)-1,4,5a,6-tetrahydro-3-Methyl-1,7-dioxo-3H,7H-azeto[2,1-b]furo[3,4-d][1,3]thiazin-6-yl]-4-thiazoleacetaMide;Cefdinir Lactone Discontinued

Chemical Property of Cefdinir Lactone

Chemical Property:

• PSA: 200.75000
• Density: 2.08±0.1 g/cm3 (20 °C, 760 mmHg)
• LogP: 0.41290

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cefdinir Lactone

There total 4 articles about Cefdinir Lactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 1.0%

cefdinir (91832-40-5,178601-88-2) → cefdinir lactone (946573-41-7)

Guidance literature:

With trifluoroacetic acid; In water; at 35 - 40 ℃; for 1h;

DOI:10.1080/00397910701397284

Reference yield:

S-2-benzothiazolyl (Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyimino thioacetate (104797-47-9) → cefdinir lactone (946573-41-7)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran; H₂O / 6 h / 15 - 20 °C

2: ammonium chloride; potassium carbonate; water / 18 - 22 °C / pH 8 - 8.2

3: 1 percent / trifluoroacetic acid / H₂O / 1 h / 35 - 40 °C

With ammonium chloride; water; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; water;

DOI:10.1080/00397910701397284

Reference yield:

C16H15N5O6S2 (127770-93-8) → cefdinir lactone (946573-41-7)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium chloride; potassium carbonate; water / 18 - 22 °C / pH 8 - 8.2

2: 1 percent / trifluoroacetic acid / H₂O / 1 h / 35 - 40 °C

With ammonium chloride; water; potassium carbonate; trifluoroacetic acid; In water;

DOI:10.1080/00397910701397284

upstream raw materials:

cefdinir

S-2-benzothiazolyl (Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyimino thioacetate

C₁₆H₁₅N₅O₆S₂

(Z)-2-(2-amino-4-thiazolyl)-2-(acetoxyimino)acetic acid

Refernces