S-1,1-dioxide-tetrahydro-3H-Pyrrolo[1,2-c][1,2,3]oxathiazole

Base Information

• Chemical Name: S-1,1-dioxide-tetrahydro-3H-Pyrrolo[1,2-c][1,2,3]oxathiazole
• CAS No.: 132635-95-1
• Molecular Formula: C5H9NO3S
• Molecular Weight: 163.197
• Hs Code.: 2934999090
• Mol file: 132635-95-1.mol

Synonyms:S-1,1-dioxide-tetrahydro-3H-Pyrrolo[1,2-c][1,2,3]oxathiazole;(S)-4,5,6-Tetrahydro-3H-pyrrolo[1,2-c]oxathiazole 1,1-dioxide

Chemical Property of S-1,1-dioxide-tetrahydro-3H-Pyrrolo[1,2-c][1,2,3]oxathiazole

Chemical Property:

• Boiling Point: 254.9±23.0 °C(Predicted)
• PKA: -6.81±0.20(Predicted)
• PSA: 54.99000
• Density: 1.51±0.1 g/cm3(Predicted)
• LogP: 0.74450

Purity/Quality:

NLT 98% ^*data from raw suppliers

(S)-4,5,6-Tetrahydro-3H-pyrrolo[1,2-C]oxathiazole1,2-Dioxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of S-1,1-dioxide-tetrahydro-3H-Pyrrolo[1,2-c][1,2,3]oxathiazole

There total 2 articles about S-1,1-dioxide-tetrahydro-3H-Pyrrolo[1,2-c][1,2,3]oxathiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-(R,S)-5-(S)-<3.3.0>-1-aza-2-thia-3-oxabicyclooctane-2-oxide (1013941-83-7) → 5-(S)-<3.3.0>-1-aza-2-thia-3-oxabicyclooctane-2,2-dioxide (132635-95-1)

Guidance literature:

With ruthenium(IV) oxide; sodium periodate; In water; ethyl acetate; at 0 ℃; for 0.5h;

DOI:10.1016/S0957-4166(00)82278-8

Reference yield: 72.7%

(S)-1-Pyrrolidin-2-yl-methanol (23356-96-9) → 5-(S)-<3.3.0>-1-aza-2-thia-3-oxabicyclooctane-2,2-dioxide (132635-95-1)

Guidance literature:

With pyridine; sulfuryl dichloride; In dichloromethane; at -68 - 20 ℃;

Reference yield: 99.0%

(4S,5S)-4,5-diphenyl-1-(2,4,6-trimethylbenzyl)imidazoline (1366473-03-1) + 5-(S)-<3.3.0>-1-aza-2-thia-3-oxabicyclooctane-2,2-dioxide (132635-95-1) → (S)-2-(((4S,5S)-4,5-diphenyl-1-(2,4,6-trimethylbenzyl)-4,5-dihydro-1H-imidazol-3-ium-3-yl)methyl)pyrrolidine-1-sulfonate (1352007-84-1)

Guidance literature:

In dichloromethane; at 20 ℃; for 168h;

DOI:10.1016/j.tetasy.2011.09.018

upstream raw materials:

2-(R,S)-5-(S)-<3.3.0>-1-aza-2-thia-3-oxabicyclooctane-2-oxide

(S)-1-Pyrrolidin-2-yl-methanol

Downstream raw materials:

(S)-2-(1-piperidinylmethyl)pyrrolidine

(S)-4-[(2-pyrrolidinyl)methyl]morpholine

(2S)-2-(methoxymethyl)-1-pyrrolidine

(S)-2-(((4S,5S)-4,5-diphenyl-1-(2,4,6-trimethylbenzyl)-4,5-dihydro-1H-imidazol-3-ium-3-yl)methyl)pyrrolidine-1-sulfonate

Refernces

• 1、 Alker,Doyle,Harwood,McGregor. "The direct synthesis of the cyclic sulphamidate of (S)-prolinol: Simultaneous N-protection and activation towards nucleophilic displacement of oxygen". . p. 877 - 880. Retrieved 1990.
• 2、 -. "METHODS FOR WOUND HEALING AND SCAR PREVENTION". Paragraph 0070; 0071; 0072. . Retrieved 2017/09/29.
• 3、 Bobin, Mariusz,Day, Iain J.,Roe, Stephen M.,Viseux, Eddy M. E.. "Insights into the mechanism for gold catalysis: Behaviour of gold(i) amide complexes in solution". . p. 6592 - 6602. Retrieved 2013/07/26.