2-(2-Chloro ethoxy) Ethyl acetate

Base Information

• Chemical Name: 2-(2-Chloro ethoxy) Ethyl acetate
• CAS No.: 14258-40-3
• Molecular Formula: C6H11ClO3
• Molecular Weight: 166.605
• Hs Code.: 2915390090
• Mol file: 14258-40-3.mol

Synonyms:Ethanol,2-(2-chloroethoxy)-, acetate (7CI,8CI,9CI);NSC 72730;Ethanol,2-(2-chloroethoxy)-, 1-acetate;Ethyl (2-chloroethoxy)acetate;1-Acetoxy-2-(2-chloroethoxy)ethane;

Chemical Property of 2-(2-Chloro ethoxy) Ethyl acetate

Chemical Property:

• Vapor Pressure: 0.1mmHg at 25°C
• Refractive Index: 1.427
• Boiling Point: 222.663 °C at 760 mmHg
• Flash Point: 92.172 °C
• PSA: 35.53000
• Density: 1.12 g/cm³
• LogP: 0.80490
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-(2-Chloroethoxy)ethylacetate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-Chloro ethoxy) Ethyl acetate

There total 12 articles about 2-(2-Chloro ethoxy) Ethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

acetic anhydride (108-24-7) + 2-(2-Chloroethoxy)ethanol (628-89-7) → 2-(2-chloroethoxy)ethyl ethanoate (14258-40-3)

Guidance literature:

at 20 ℃;

DOI:10.1021/jo102185d

Reference yield: 78.0%

→ 2-(2-chloroethoxy)ethyl ethanoate (14258-40-3) + 2-(2-iodoethoxy)ethyl acetate (290344-86-4)

Guidance literature:

Reference yield: 73.0%

2-(2-Chloroethoxy)ethanol (628-89-7) + 4-nitrobenzyl 2,2,2-trichloroethanimidoate (163193-79-1) → 2-(2-chloroethoxy)ethyl ethanoate (14258-40-3) + 2-(2-chloroethoxy)ethyl p-nitrobenzyl ether

Guidance literature:

With trifluorormethanesulfonic acid; In 1,4-dioxane; at 20 ℃; for 6.5h; Solvent; Inert atmosphere;

DOI:10.1021/acs.joc.8b00331

upstream raw materials:

2-(2-Chloroethoxy)ethanol

sodium acetate

3-oxa-1,5-dichloropentane

1,4-dioxane

Downstream raw materials:

4-(2(2-hydroxyethoxy)ethyl)-morpholine

2-[2-(diethylamino)ethoxy] ethanol

2-(2-Chloroethoxy)ethanol

4-(Z-N-2-aminoethanamido)-N₁,N₇-bis[2-(2-acetoxyethoxy)ethyl]-4-{3-[2-(2-acetoxyethoxy)ethylamino]-3-oxopropyl}heptanediamide

Refernces

• 1、 Fitch, John W.,Payne, Wyatt G.,Westmoreland, Donald. "Platinum-Catalyzed Acylative Cleavage of Cyclic Ethers". . p. 751 - 753. Retrieved 1983.
• 2、 -. "HYDANTOIN CONTAINING DEOXYURIDINE TRIPHOSPHATASE INHIBITORS". Paragraph 0927. . Retrieved 2018/06/12.
• 3、 -. "THIAZOLIDINONE COMPOUNDS AND USE THEREOF". Paragraph 0990-0991. . Retrieved 2017/09/21.