5-(2-Hydroxyethyl)-2-methoxyphenol

Base Information

• Chemical Name: 5-(2-Hydroxyethyl)-2-methoxyphenol
• CAS No.: 50602-41-0
• Molecular Formula: C₉H₁₂O₃
• Molecular Weight: 168.192
• European Community (EC) Number: 862-370-7
• Nikkaji Number: J656.796G
• Wikidata: Q105213044
• ChEMBL ID: CHEMBL4063982
• Mol file: 50602-41-0.mol

Synonyms:5-(2-hydroxyethyl)-2-methoxyphenol;50602-41-0;3-hydroxy-4-methoxyBenzeneethanol;Benzeneethanol, 3-hydroxy-4-methoxy-;2-(3-hydroxy-4-methoxyphenyl)ethanol;SCHEMBL2632685;CHEMBL4063982;PPUFZEKAOXNVLU-UHFFFAOYSA-N;BCP30369;3-hydroxy-4-methoxyphenethyl alcohol;AKOS006316325;CS-0247395;FT-0730650;EN300-365393;Z1198339386;5-(2-Hydroxyethyl)-2-methoxyphenol pound>>2-(3-hydroxy-4-methoxyphenyl)ethanol

Chemical Property of 5-(2-Hydroxyethyl)-2-methoxyphenol

Chemical Property:

• XLogP3: 0.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 168.078644241
• Heavy Atom Count: 12
• Complexity: 127

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)CCO)O

Technology Process of 5-(2-Hydroxyethyl)-2-methoxyphenol

There total 19 articles about 5-(2-Hydroxyethyl)-2-methoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

methyl 3-hydroxy-4-methoxyphenylacetate (15964-81-5) → 3-hydroxy-4-methoxyphenethyl alcohol (50602-41-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 12h; Heating;

DOI:10.1080/00397919508015856

Reference yield: 70.0%

ethyl (3-hydroxy-4-methoxyphenyl)acetate → 3-hydroxy-4-methoxyphenethyl alcohol (50602-41-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; Inert atmosphere; Reflux;

DOI:10.1016/j.bmc.2017.01.050

Reference yield: 62.0%

2-(4-Methoxyphenyl)ethanol (702-23-8) → 3-hydroxy-4-methoxyphenethyl alcohol (50602-41-0)

Guidance literature:

2-(4-Methoxyphenyl)ethanol; With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In tetrahydrofuran; n-heptane; cyclohexane; for 0.166667h; cooling;

With Trimethyl borate; In tetrahydrofuran; n-heptane; cyclohexane; cooling;

With dihydrogen peroxide; acetic acid; In tetrahydrofuran; n-heptane; cyclohexane; at 0 - 20 ℃; Further stages.;

DOI:10.1016/j.tet.2007.03.022

upstream raw materials:

methanol

3-hydroxy-4-methoxystyrene

methyl 3-hydroxy-4-methoxyphenylacetate

2-(5-(benzyloxy)-4-methoxyphenyl)-ethan-1-ol

Downstream raw materials:

2-(3-hydroxy-4-methoxyphenyl)ethyl (R)-2-(4-fluoro-3-nitrobenzyl)-4-methoxy-3-(4-methoxyphenyl)-5-oxo-2,5-dihydrofuran-2-carboxylate

hydroxytyrosol

2-(5-(benzyloxy)-4-methoxyphenyl)-ethan-1-ol

2-(3-hydroxy-4-methoxyphenyl)acetaldehyde

Refernces

• 1、 Emmetiere, Fabien,Grenning, Alexander J.. "Functional Group Interconversion of Alkylidenemalononitriles to Primary Alcohols by a Cooperative Redox Operation". . p. 3077 - 3085. Retrieved 2020/08/10.
• 2、 Cardinal, Sébastien,Paquet-C?té, Pierre-Alexandre,Azelmat, Jabrane,Bouchard, Corinne,Grenier, Daniel,Voyer, Normand. "Synthesis and anti-inflammatory activity of isoquebecol". . p. 2043 - 2056. Retrieved 2017/03/23.