4-Bromo-2-chlorobenzamide

Base Information

• Chemical Name: 4-Bromo-2-chlorobenzamide
• CAS No.: 426265-73-8
• Molecular Formula: C7H5BrClNO
• Molecular Weight: 234.48
• Hs Code.: 2924299090
• Mol file: 426265-73-8.mol

Synonyms:4-Bromo-2-chlorobenzamide

Chemical Property of 4-Bromo-2-chlorobenzamide

Chemical Property:

• PSA: 43.09000
• LogP: 2.90170

Purity/Quality:

97% ^*data from raw suppliers

4-Bromo-2-chlorobenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Bromo-2-chlorobenzamide

There total 4 articles about 4-Bromo-2-chlorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ 4-bromo-2-chlorobenzamide (426265-73-8)

Guidance literature:

Reference yield: 87.0%

oxalyl dichloride (79-37-8) + 4-Bromo-2-chloro-benzoic Acid (59748-90-2) → 4-bromo-2-chlorobenzamide (426265-73-8)

Guidance literature:

With ammonium hydroxide;

Reference yield: 65.0%

p-bromobenzamide (698-67-9) → 4-bromo-2-chlorobenzamide (426265-73-8)

Guidance literature:

With N-chloro-succinimide; palladium diacetate; trifluoroacetic acid; In 1,2-dichloro-ethane; at 90 ℃; for 24h; regioselective reaction; Sealed tube;

DOI:10.1016/j.catcom.2019.105784

upstream raw materials:

4-bromo-2-chlorobenzonitrile

oxalyl dichloride

4-Bromo-2-chloro-benzoic Acid

p-bromobenzamide

Downstream raw materials:

2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide

2-chloro-4-(3-((2-oxo-1,2-dihydroquinolin-6-yl)methyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-yl)benzamide

2-chloro-4-(3-(quinolin-6-ylmethyl)-3H-imidazo[4,5-b]pyridin-5-yl)benzamide

2-chloro-4-(3-(quinolin-6-ylmethyl)-3H-imidazo[4,5-b]pyridin-5-yl)benzamide hydrochloride

Refernces

• 1、 -. "TRICYCLIC PI3K INHIBITOR COMPOUNDS AND METHODS OF USE". . . Retrieved 2018/03/25.
• 2、 -. "4- (4- (IMIDAZOL-4-YL) PYRIMIDIN-2-YLAMINO) BENZAMIDES AS CDK INHIBITORS". Page/Page column 61. . Retrieved 2008/06/13.