LY2584702

Base Information

• Chemical Name: LY2584702
• CAS No.: 1082949-67-4
• Molecular Formula: C21H19F4N7
• Molecular Weight: 445.422
• Hs Code.: 2933998090
• Mol file: 1082949-67-4.mol

Synonyms:LY2584702;LY-2584702 (free base);LY2584702 TsOH;4-[4-[4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-imidazol-2-yl]-1-piperidyl]-1H-pyrazolo[3,4-d]pyrimidine LY2584702;4-[4-[4-[4-Fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl]-1-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidine

Chemical Property of LY2584702

Chemical Property:

• PSA: 75.52000
• LogP: 4.36030
• Storage Temp.: RT (des.)
• Solubility.: Soluble in DMSO (up to 1 mg/ml) or in DMF (up to 3 mg/ml).

Purity/Quality:

98% min ^*data from raw suppliers

LY2584702 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: LYS6K2 (1082949-67-4) is a selective inhibitor of the p70 ribosomal S6 kinase (S6K).1 Blocks the phosphorylation of S6 at concentrations as low as 0.1-0.3 μM with no activity at GSK3β and Erk1/2 at 10 μM.2?LYS6K2 is a useful tool to dissect insulin receptor signaling pathways and was employed to show that the action of mTORC1 on SREB P-1c expression is not mediated by S6K.2?Cell permeable.
• Uses: LY 2584702 is an orally available inhibitor of p70S6K signalling and potential antineoplastic activity. Used in combination with Erlotinib or Everolimus as an anti-tumor treatment.

Technology Process of LY2584702

There total 1 articles about LY2584702 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

tert-butyl 4-(4-(4-fluoro-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazol-2-yl)piperidine-1-carboxylate (1082950-60-4) + 4-chloro-1H-pyrazolo[3,4-d]pyrimidine (5399-92-8) → 4-[4-[4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl]-1-piperidinyl]-1H-pyrazol[3,4-d]pyrimidine (1082949-67-4)

Guidance literature:

tert-butyl 4-(4-(4-fluoro-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazol-2-yl)piperidine-1-carboxylate; With methanol; acetyl chloride; at 5 - 20 ℃;

With triethylamine; In dimethyl sulfoxide; for 0.5h;

4-chloro-1H-pyrazolo[3,4-d]pyrimidine; In dimethyl sulfoxide; at 20 ℃; Product distribution / selectivity;

Reference yield: 98.47%

4-[4-[4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl]-1-piperidinyl]-1H-pyrazol[3,4-d]pyrimidine (1082949-67-4) → 4-{4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl}-1H-pyrazolo[3,4-d]pyrimidine hydrochloride (1082948-81-9)

Guidance literature:

With hydrogenchloride; In dichloromethane; at 20 ℃; for 1h;

Reference yield: 86.0%

4-[4-[4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl]-1-piperidinyl]-1H-pyrazol[3,4-d]pyrimidine (1082949-67-4) + toluene-4-sulfonic acid (104-15-4) → 4-{4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl}-1H-pyrazolo[3,4-d]pyrimidine p-toluenesulfonate (1082949-68-5)

Guidance literature:

In water; acetone; at 20 - 55 ℃; for 2.33h; Product distribution / selectivity;

upstream raw materials:

tert-butyl 4-(4-(4-fluoro-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazol-2-yl)piperidine-1-carboxylate

4-chloro-1H-pyrazolo[3,4-d]pyrimidine

Downstream raw materials:

4-{4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl}-1H-pyrazolo[3,4-d]pyrimidine p-toluenesulfonate

4-{4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl}-1H-pyrazolo[3,4-d]pyrimidine hydrochloride

Refernces