R-Cyclopropylglycine Methyl ester hydrochloride

Base Information

• Chemical Name: R-Cyclopropylglycine Methyl ester hydrochloride
• CAS No.: 138326-69-9
• Molecular Formula: C₆H₁₁NO₂*ClH
• Molecular Weight: 165.62
• Mol file: 138326-69-9.mol

Synonyms:R-Cyclopropylglycine Methyl ester hydrochloride;Methyl (R)-a-Amino-cyclopropaneacetate HCl

Chemical Property of R-Cyclopropylglycine Methyl ester hydrochloride

Chemical Property:

• PSA: 52.32000
• LogP: 1.39900

Purity/Quality:

98.5% ^*data from raw suppliers

(R)-AMINO-CYCLOPROPYL-ACETIC ACID METHYL ESTER HCL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of R-Cyclopropylglycine Methyl ester hydrochloride

There total 1 articles about R-Cyclopropylglycine Methyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.6%

N-(R)-2-(tertbutoxycarbonylamino)-2-cyclopropylacetic acid (54256-41-6) → (R)-methyl 2-amino-2-cyclopropylacetate hydrochloride (138326-69-9)

Guidance literature:

With methanol; thionyl chloride; at 0 ℃; for 0.5h;

Reference yield:

(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-methyl-pyrrolidine-2-carboxylic acid (1354693-55-2) + (R)-methyl 2-amino-2-cyclopropylacetate hydrochloride (138326-69-9) → (R)-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-methyl-pyrrolidine-2-carbonyl]-amino}-cyclopropyl-acetic acid (1354692-87-7)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 14 h / 20 °C

2: lithium hydroxide / tetrahydrofuran; methanol / 3 h / 20 °C

With N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;

upstream raw materials:

N-(R)-2-(tertbutoxycarbonylamino)-2-cyclopropylacetic acid

Downstream raw materials:

(R)-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-methyl-pyrrolidine-2-carbonyl]-amino}-cyclopropyl-acetic acid

Refernces