FMOC-4-[2-(BOC-AMINO)ETHOXY]-L-PHENYLALANINE

Base Information

• Chemical Name: FMOC-4-[2-(BOC-AMINO)ETHOXY]-L-PHENYLALANINE
• CAS No.: 1013883-02-7
• Molecular Formula: C31H34N2O7
• Molecular Weight: 546.61
• Mol file: 1013883-02-7.mol

Synonyms:FMOC-4-[2-(BOC-AMINO)ETHOXY]-L-PHENYLALANINE;Fmoc-4-[2-(Boc-amino)ethoxy]-Phe-OH;N-Fmoc-4-[2-(Boc-amino)ethoxy]-L-phenylalanine;O-[2-[[(1,1-Dimethylethoxy)carbonyl]amino]ethyl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-tyrosine;Fmoc-4-[2-(Boc-amino)ethoxy]-phenylalanine

Chemical Property of FMOC-4-[2-(BOC-AMINO)ETHOXY]-L-PHENYLALANINE

Chemical Property:

• Boiling Point: 759.1±60.0 °C(Predicted)
• PKA: 2.96±0.10(Predicted)
• PSA: 123.19000
• Density: 1.245±0.06 g/cm3(Predicted)
• LogP: 5.90630

Purity/Quality:

≥98%, ^*data from raw suppliers

Fmoc-4-[2-(Boc-amino)ethoxy]-L-phenylalanine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: FMOC-4-[2-(BOC-AMINO)ETHOXY]-L-PHENYLALANINE can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes.

Technology Process of FMOC-4-[2-(BOC-AMINO)ETHOXY]-L-PHENYLALANINE

There total 5 articles about FMOC-4-[2-(BOC-AMINO)ETHOXY]-L-PHENYLALANINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.7%

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) + O-[2-[[tert-butoxycarbonyl]amino]ethyl]-L-tyrosine → FMOC-4-[2-(Boc-aminoethoxy)]-L-phenylalanine (1013883-02-7)

Guidance literature:

With sodium carbonate; In tetrahydrofuran; water; at 20 ℃;

Reference yield:

L-tyrosine (60-18-4,18875-48-4,25619-78-7,30704-25-7) → FMOC-4-[2-(Boc-aminoethoxy)]-L-phenylalanine (1013883-02-7)

Guidance literature:

Multi-step reaction with 5 steps

1: thionyl chloride / -10 °C / Reflux

2: pyridine / dichloromethane / 0 °C / Reflux

3: di-tert-butyl-diazodicarboxylate; triphenylphosphine / toluene / 0 - 20 °C

4: water; sodium hydroxide / ethanol / 20 °C

5: sodium carbonate / water; tetrahydrofuran / 20 °C

With pyridine; thionyl chloride; di-tert-butyl-diazodicarboxylate; water; sodium carbonate; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; toluene;

Reference yield:

L-tyrosine methyl ester HCl (3417-91-2) → FMOC-4-[2-(Boc-aminoethoxy)]-L-phenylalanine (1013883-02-7)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine / dichloromethane / 0 °C / Reflux

2: di-tert-butyl-diazodicarboxylate; triphenylphosphine / toluene / 0 - 20 °C

3: water; sodium hydroxide / ethanol / 20 °C

4: sodium carbonate / water; tetrahydrofuran / 20 °C

With pyridine; di-tert-butyl-diazodicarboxylate; water; sodium carbonate; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; toluene;

upstream raw materials:

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

L-tyrosine

L-tyrosine methyl ester HCl

methyl (2,2,2-trifluoroacetyl)-L-tyrosinate

Refernces