N-(2-Aminophenyl)acetamide

Base Information

• Chemical Name: N-(2-Aminophenyl)acetamide
• CAS No.: 34801-09-7
• Molecular Formula: C8H10N2O
• Molecular Weight: 150.18
• Hs Code.: 2924299090
• European Community (EC) Number: 627-665-5
• NSC Number: 16117
• UNII: LB34XRQ95V
• DSSTox Substance ID: DTXSID4043854
• Nikkaji Number: J43.350K
• Wikidata: Q27890211
• Mol file: 34801-09-7.mol

Synonyms:2'-Aminoacetanilide;N-(2-Aminophenyl)acetamide;34801-09-7;o-aminoacetanilide;Acetamide, N-(2-aminophenyl)-;N-Acetyl-2-aminoaniline;N-Acetyl-o-phenylenediamine;MFCD00210388;LB34XRQ95V;NSC 16117;NSC-16117;2'-Acetamidoaniline;2-ACETAMIDOANILINE;UNII-LB34XRQ95V;TimTec1_004882;2'-Aminoacetanilide, 98%;AMINOACETANILIDE, O-;Oprea1_268954;SCHEMBL463597;N-(2-amino-phenyl)-acetamide;N-Acetyl-1,2-phenylenediamine;DTXSID4043854;HMS1547N20;AMY20711;NSC16117;BBL002386;STK500749;AKOS000100447;CS-W008938;MS-1760;SB75765;SY050887;2 inverted exclamation mark -Aminoacetanilide;FT-0679174;EN300-137656;N10407;A874858;AE-641/00627026;J-019760;Q27890211;Z239120544

Chemical Property of N-(2-Aminophenyl)acetamide

Chemical Property:

• Melting Point: 133-137 °C(lit. )
• Refractive Index: 1.6180 (estimate)
• Boiling Point: 361.5 °C at 760 mmHg
• PKA: 14.73±0.70(Predicted)
• Flash Point: 172.4 °C
• PSA: 55.12000
• Density: 1.203 g/cm³
• LogP: 1.88140
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Water Solubility.: 107.5g/L(22 oC)
• XLogP3: 0
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 150.079312947
• Heavy Atom Count: 11
• Complexity: 147

Purity/Quality:

98%,99%, ^*data from raw suppliers

2''-Aminoacetanilide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(=O)NC1=CC=CC=C1N
• Uses: 2′-Aminoacetanilide may be used in the preparation of:2-Methylbenzimidazole.N-(2-(1,3-Dimethyl-2,4-dioxo-5-phenyl-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)phenyl)-5-methylfuran-2-carboxamide, a potent cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor.Azobenzothiazole dyes, N-[2-(6-nitrobenzothiazol-2-ylazo)phenyl]acetamide and N-[2-(benzothiazol-2-ylazo)phenyl]acetamide.

Technology Process of N-(2-Aminophenyl)acetamide

There total 27 articles about N-(2-Aminophenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

o-nitroacetanilide (552-32-9) → N-(2-aminophenyl)acetamide (34801-09-7)

Guidance literature:

With 5% Pd/C; hydrazine; In ethanol; at 95 ℃;

DOI:10.1021/jo8014424

Reference yield: 97.0%

2-acetamidoazobenzene (17716-46-0) → N-(2-aminophenyl)acetamide (34801-09-7)

Guidance literature:

With iron; acetic acid; In ethanol; at 20 ℃; for 24h; Inert atmosphere;

Reference yield: 95.0%

2-aminoacetophenone (551-93-9) → N-(2-aminophenyl)acetamide (34801-09-7)

Guidance literature:

With hydroxylamine hydrochloride; phosphorus pentoxide; silica gel; for 0.0833333h; microwave irradiation;

DOI:10.1081/SCC-120022469

upstream raw materials:

o-nitroacetanilide

N,N'-(o-phenylene)di(acetamide)

oxalic acid

acetic anhydride

Downstream raw materials:

acetic acid-(2-trans-cinnamylidenamino-anilide)

acetic acid-[2-amino-5-(3-nitro-phenylazo)-anilide]

acetic acid-{2-[3-(2-nitro-phenyl)-triazenyl]-anilide}

2-Methyl-1H-benzimidazole

Refernces

• 1、 Chand, Dillip Kumar,Rai, Randhir. "Copper nanoparticles (CuNPs) catalyzed chemoselective reduction of nitroarenes in aqueous medium". . . Retrieved 2021/08/20.
• 2、 Nakane, Keita,Sato, Shinichi,Niwa, Tatsuya,Tsushima, Michihiko,Tomoshige, Shusuke,Taguchi, Hideki,Ishikawa, Minoru,Nakamura, Hiroyuki. "Proximity Histidine Labeling by Umpolung Strategy Using Singlet Oxygen". supporting information. p. 7726 - 7731. Retrieved 2021/05/29.