Propanoic acid, 2-Methyl-2-(phenylthio)-

Base Information

• Chemical Name: Propanoic acid, 2-Methyl-2-(phenylthio)-
• CAS No.: 5219-64-7
• Molecular Formula: C10H12O2S
• Molecular Weight: 196.27
• Hs Code.: 2930909090
• Mol file: 5219-64-7.mol

Synonyms:2-Methyl-2-(phenylthio)-propionic acid;Propionic acid,2-methyl-2-(phenylthio);Sch 1600;2-Methyl-2-(phenylthio)-Propanoicacid;

Chemical Property of Propanoic acid, 2-Methyl-2-(phenylthio)-

Chemical Property:

• Vapor Pressure: 0.000112mmHg at 25°C
• Melting Point: 65-66 °C
• Boiling Point: 322.9°Cat760mmHg
• PKA: 3.80±0.10(Predicted)
• Flash Point: 149.1°C
• PSA: 62.60000
• Density: 1.18g/cm³
• LogP: 2.64190

Purity/Quality:

98%Min ^*data from raw suppliers

2-methyl-2-(phenylsulfanyl)propanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Propanoic acid, 2-Methyl-2-(phenylthio)-

There total 6 articles about Propanoic acid, 2-Methyl-2-(phenylthio)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.1%

methyl 2-methyl-2-(phenylsulfanyl)propionate (68734-79-2) → 2-methyl-2-(phenylthio)propanoic acid (5219-64-7)

Guidance literature:

methyl 2-methyl-2-(phenylsulfanyl)propionate; With methanol; lithium hydroxide; water; In tetrahydrofuran; at 20 ℃;

With hydrogenchloride; In dihydrogen peroxide; pH=2;

Reference yield: 62.0%

chloroform (67-66-3,8013-54-5) + thiophenol (108-98-5) + acetone (67-64-1) → 2-methyl-2-(phenylthio)propanoic acid (5219-64-7)

Guidance literature:

With sodium hydroxide; for 24h; Ambient temperature;

Reference yield:

thiophenol (108-98-5) → 2-methyl-2-(phenylthio)propanoic acid (5219-64-7)

Guidance literature:

With sodium hydroxide; In chloroform; water; acetone;

upstream raw materials:

ethyl 2-bromoisobutyrate

sodium thiophenolate

2-bromo-2-methylpropionic acid

thiophenol

Downstream raw materials:

2-methyl-2-(phenylthio)propanoyl chloride

α-benzenesulfinyl-isobutyric acid

1-ethoxycarbonyl-1-methylethyl phenyl sulfide

catena-{aquabis(2-methyl-2-(phenylthio)-propanoato)cadmium(II) monohydrate}

Refernces

• 1、 -. "2-Methylprop anamides and their use as pharmaceuticals". Page/Page column 35. . Retrieved 2010/02/15.
• 2、 -. "Antihypercholesterolemic compounds". . . Retrieved 2008/06/13.