2,3,5,6-Tetrachloroanisidine

Base Information

• Chemical Name: 2,3,5,6-Tetrachloroanisidine
• CAS No.: 70439-96-2
• Molecular Formula: C7H5Cl4NO
• Molecular Weight: 260.935
• UNII: 1318C52Y93
• DSSTox Substance ID: DTXSID00220701
• Nikkaji Number: J146.717D
• Wikidata: Q27251457
• Mol file: 70439-96-2.mol

Synonyms:2,3,5,6-Tetrachloroanisidine;70439-96-2;Benzenamine, 2,3,5,6-tetrachloro-4-methoxy-;1318C52Y93;2,3,5,6-Tetrachloro-4-methoxyaniline;Tetrachloro-p-anisidine;UNII-1318C52Y93;TETRACHLOROANISIDINE;SCHEMBL10947434;DTXSID00220701;MBYRIGCRDZOZTI-UHFFFAOYSA-N;2,3,5,6-Tetrachloro-4-methoxyaniline #;2,3,5,6-TETRACHLORO-4- METHOXYBENZENAMINE;Q27251457

Chemical Property of 2,3,5,6-Tetrachloroanisidine

Chemical Property:

• Vapor Pressure: 0.000124mmHg at 25°C
• Boiling Point: 335°Cat760mmHg
• Flash Point: 156.4°C
• PSA: 35.25000
• Density: 1.595g/cm³
• LogP: 4.47220
• XLogP3: 4.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 260.909574
• Heavy Atom Count: 13
• Complexity: 166

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C(=C(C(=C1Cl)Cl)N)Cl)Cl

Technology Process of 2,3,5,6-Tetrachloroanisidine

There total 6 articles about 2,3,5,6-Tetrachloroanisidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3,5-dichloro-4-methoxyaniline (32407-11-7) → 2,3,5,6-tetrachloroanisidine (70439-96-2)

Guidance literature:

With N-chloro-succinimide; In toluene; at 80 ℃; for 1h;

DOI:10.1007/s002440010298

Reference yield:

2,6-dichloro-4-nitro-anisole (17742-69-7) → 2,3,5,6-tetrachloroanisidine (70439-96-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / SnCl₂*2H₂O / ethanol; HCl / 1 h / 60 °C

2: 90 percent / NCS / toluene / 1 h / 80 °C

With N-chloro-succinimide; tin(ll) chloride; In hydrogenchloride; ethanol; toluene;

DOI:10.1007/s002440010298

Reference yield:

N-(2,3,5,6-tetrachloro-4-methoxyphenyl)acetamide (77218-84-9) → 2,3,5,6-tetrachloroanisidine (70439-96-2)

Guidance literature:

With sodium hydroxide; ethanol;

upstream raw materials:

N-(2,3,5,6-tetrachloro-4-methoxyphenyl)acetamide

2,3,5,6-Tetrachlor-4-fluor-anilin

sodium methylate

3,5-dichloro-4-methoxyaniline

Downstream raw materials:

2,3,5,6-tetrachlorohydroquinone diacetate

4-Diazo-2,3,5,6-tetrachlorocyclohexa-2,5-diene-1-one

4-iodo-2,3,5,6-tetrachloroanisole

Drosophilin A

Refernces