(R)-A-HYDROXY-3-FURANACETONITRILE

Base Information

• Chemical Name: (R)-A-HYDROXY-3-FURANACETONITRILE
• CAS No.: 188481-45-0
• Molecular Formula: C6H5NO2
• Molecular Weight: 0
• Mol file: 188481-45-0.mol

Synonyms:(R)-A-HYDROXY-3-FURANACETONITRILE

Chemical Property of (R)-A-HYDROXY-3-FURANACETONITRILE

Chemical Property:

• PSA: 57.16000
• LogP: 0.83658

Purity/Quality:

99% ^*data from raw suppliers

(R)-ALPHA-HYDROXY-3-FURANACETONITRILE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-A-HYDROXY-3-FURANACETONITRILE

There total 2 articles about (R)-A-HYDROXY-3-FURANACETONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

furan-3-carboxaldehyde (498-60-2) + hydrogen cyanide (74-90-8) → (R)-2-(furan-3-yl)-2-hydroxyacetonitrile (188481-45-0,174754-57-5)

Guidance literature:

In di-isopropyl ether; for 4h; Ambient temperature; (R)-oxynitrilase;

DOI:10.1016/S0957-4166(96)00528-9

Reference yield:

furan-3-carboxaldehyde (498-60-2) + hydrogen cyanide (74-90-8) → (S)-Furan-3-yl-hydroxy-acetonitrile + (R)-2-(furan-3-yl)-2-hydroxyacetonitrile (188481-45-0,174754-57-5)

Guidance literature:

In di-isopropyl ether; at 25 ℃; for 6.5h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; hydroxynitrile lyase (S)-MeHNL (EC 4.1.2.37), nitrocellulose;

Reference yield:

(S)-2-methoxy-2-phenylacetic acid (26164-26-1) + (R)-2-(furan-3-yl)-2-hydroxyacetonitrile (188481-45-0,174754-57-5) → C15H13NO4

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1039/b517917c

upstream raw materials:

furan-3-carboxaldehyde

hydrogen cyanide

Refernces

• 1、 Foerster, Siegfried,Roos, Juergen,Effenberger, Franz,Wajant, Harald,Sprauer, Achim. "Ueber die erste rekombinante Hydroxynitril-Lyase und ihre Anwendung in der Synthese von (S)-Cyanhydrinen". . p. 493 - 494. Retrieved 2007/10/03.