2-Amino-isonicotinic acid hydrazide

Base Information

• Chemical Name: 2-Amino-isonicotinic acid hydrazide
• CAS No.: 58481-01-9
• Molecular Formula: C₆H₈N₄O
• Molecular Weight: 152.156
• Hs Code.: 29333990
• Mol file: 58481-01-9.mol

Synonyms:2-Aminopyridine-4-carbohydrazide;

Chemical Property of 2-Amino-isonicotinic acid hydrazide

Chemical Property:

• Melting Point: 190.9-191.3 °C
• Refractive Index: 1.651
• PKA: 11.23±0.10(Predicted)
• PSA: 94.03000
• Density: 1.352 g/cm³
• LogP: 0.93970

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-aminopyridine-4-carbohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Amino-isonicotinic acid hydrazide

There total 4 articles about 2-Amino-isonicotinic acid hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methyl 2-aminoisonicotinate (6937-03-7) → 2-aminoisonicotinic acid hydrazide (58481-01-9)

Guidance literature:

With hydrazine hydrate; In methanol; for 3h; Heating;

Reference yield:

2-amino-4-ethoxycarbonyl-pyridine (13362-30-6) → 2-aminoisonicotinic acid hydrazide (58481-01-9)

Guidance literature:

With hydrazine hydrate; In ethanol; for 5h; Reflux;

DOI:10.1016/j.ejmech.2011.11.015

Reference yield:

2-aminoisonicotinic acid (13362-28-2) → 2-aminoisonicotinic acid hydrazide (58481-01-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / Reflux

2: hydrazine hydrate / ethanol / Reflux

With sulfuric acid; hydrazine hydrate; In ethanol;

DOI:10.1016/j.bmc.2012.03.061

upstream raw materials:

2-amino-4-ethoxycarbonyl-pyridine

methyl 2-aminoisonicotinate

2-aminoisonicotinic acid

Downstream raw materials:

2-aminoisonicotinic acid (4-fluorobenzylidine) hydrazide

4-(5-(benzylthio)-1,3,4-oxadiazol-2-yl)pyridin-2-amine

2-(5-(2-aminopyridin-4-yl)-1,3,4-oxadiazol-2-ylthio)-1-(4-bromophenyl)ethanone

2-(5-(2-aminopyridin-4-yl)-1,3,4-oxadiazol-2-ylthio)-1-phenylethanone

Refernces

• 1、 Du, Qian-Ru,Li, Dong-Dong,Pi, Ya-Zhou,Li, Jing-Ran,Sun, Jian,Fang, Fei,Zhong, Wei-Qing,Gong, Hai-Bin,Zhu, Hai-Liang. "Novel 1,3,4-oxadiazole thioether derivatives targeting thymidylate synthase as dual anticancer/antimicrobial agents". . p. 2286 - 2297. Retrieved 2013/05/09.
• 2、 Liu, Kai,Lu, Xiang,Zhang, Hong-Jia,Sun, Juan,Zhu, Hai-Liang. "Synthesis, molecular modeling and biological evaluation of 2-(benzylthio)-5-aryloxadiazole derivatives as anti-tumor agents". experimental part. p. 473 - 478. Retrieved 2012/03/13.