TALNETANT

Base Information

• Chemical Name: TALNETANT
• CAS No.: 174636-26-1
• Molecular Formula: C₂₅H₂₂N₂O₂
• Molecular Weight: 382.462
• Mol file: 174636-26-1.mol

Synonyms:TALNETANT

Chemical Property of TALNETANT

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

99% ^*data from raw suppliers

Talnetant ≥98% (HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of TALNETANT

There total 22 articles about TALNETANT which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

oxycinchophen (485-89-2) + (R)-1-phenylpropylamine (3789-59-1) → talnetant (174636-32-9,174636-26-1)

Guidance literature:

oxycinchophen; With 1,1'-carbonyldiimidazole; at 50 ℃; for 5h;

(R)-1-phenylpropylamine; at 25 - 70 ℃; for 17h;

DOI:10.1021/ol100453x

Reference yield: 80.0%

6,14,22,30-Tetraphenyl-[1,5,9,13]-tetraoxadecino[2,3-c:6,7-c':10,11c'':14,15-c''']tetraquinoline-8,16,24,32-tetrone + Ethyl 3-acetoxy-2-phenylquinoline-4-carboxylate + (R)-1-phenylpropylamine (3789-59-1) → talnetant (174636-32-9,174636-26-1)

Guidance literature:

In ethyl acetate; at 65 - 70 ℃; for 3h;

Reference yield: 79.9%

(R)-1-phenylpropylamine (3789-59-1) → talnetant (174636-32-9,174636-26-1)

Guidance literature:

oxycinchophen; With triethylamine; 1,1'-carbonyldiimidazole; In acetonitrile; at 20 - 50 ℃; for 2 - 5h;

(R)-1-phenylpropylamine; In acetonitrile; at 25 - 75 ℃; Product distribution / selectivity;

upstream raw materials:

oxycinchophen

(R)-1-phenylpropylamine

methoxymethyl phenyl ketone

3-methoxy-2-phenylquinoline-4-carboxylic cid

Downstream raw materials:

(S)-N-(α-ethylbenzyl)-3-(2-aminoethoxy)-2-phenylquinoline-4-carboxamide

Refernces

• 1、 Rohbogner, Christoph J.,Wirth, Stefan,Knochel, Paul. "Phosphorodiamidate-directed metalation of N -heterocycles using Mg- and Zn-TMP bases". supporting information; scheme or table. p. 1984 - 1987. Retrieved 2010/07/15.
• 2、 -. "METHOD FOR THE SYNTHESIS OF QUINOLIΝE DERIVATIVES". Page/Page column 20-24. . Retrieved 2008/06/13.