N,N-DiMethyl BenzilaMide

Base Information

• Chemical Name: N,N-DiMethyl BenzilaMide
• CAS No.: 30318-36-6
• Molecular Formula: C16H17NO2
• Molecular Weight: 255.316
• Hs Code.: 2924299090
• Mol file: 30318-36-6.mol

Synonyms:N,N-DiMethyl BenzilaMide;α-Hydroxy-N,N-diMethyl-α-phenylbenzeneacetaMide

Chemical Property of N,N-DiMethyl BenzilaMide

Chemical Property:

• Melting Point: 131-132 °C
• Boiling Point: 434.7±45.0 °C(Predicted)
• PKA: 11.65±0.29(Predicted)
• PSA: 40.54000
• Density: 1.154±0.06 g/cm3(Predicted)
• LogP: 2.01070

Purity/Quality:

97% ^*data from raw suppliers

N,N-DimethylBenzilamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Loperamide (L469450) impurity.

Technology Process of N,N-DiMethyl BenzilaMide

There total 12 articles about N,N-DiMethyl BenzilaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

N,N-dimethyl-2-oxo-2-phenylacetamide (51579-87-4) + phenylmagnesium bromide (100-58-3) → 2-hydroxy-N,N-dimethyl-2,2-diphenylacetamide (30318-36-6)

Guidance literature:

In diethyl ether; for 2h; Heating;

DOI:10.1021/jo00121a021

Reference yield: 29.0%

N,N-dimethyl-2,2-diphenyl-2-(phenylazo)acetamide (72572-07-7) + 2,2-dimethoxy-propane (77-76-9) → 2-hydroxymethyl-N,N-dimethyl-2,2-diphenylacetamide (72572-09-9) + 2-hydroxy-N,N-dimethyl-2,2-diphenylacetamide (30318-36-6) + 2-Methoxy-N,N-dimethyl-2,2-diphenyl-acetamide (63953-28-6)

Guidance literature:

With 2-bromo-2,2-diphenylacetamide; for 7h; Heating;

Reference yield: 20.0%

2-bromo-N,N-dimethyl-2,2-diphenylacetamide (63953-26-4) → diphenamid (957-51-7) + 2-[4-(Dimethylcarbamoyl-phenyl-methyl)-phenyl]-N,N-dimethyl-2,2-diphenyl-acetamide (63953-37-7) + 2-hydroxy-N,N-dimethyl-2,2-diphenylacetamide (30318-36-6) + 2-[4-(Dimethylcarbamoyl-diphenyl-methyl)-phenyl]-2-[4-(dimethylcarbamoyl-phenyl-methyl)-phenyl]-N,N-dimethyl-2-phenyl-acetamide (95086-93-4)

Guidance literature:

With sodium methylate; 2,2-dimethoxy-propane; acetone; for 3h; Further byproducts given; Heating;

upstream raw materials:

diphenamid

2-bromo-N,N-dimethyl-2,2-diphenylacetamide

N,N-dimethyl-2-chloro-2,2-diphenylacetamide

N,N-dimethyl-2,2-diphenyl-2-(phenylazo)acetamide

Refernces

• 1、 Sibi, Mukund P.,Marvin, Mali,Sharma, Rajiv. "α-Keto Amides and 1,2-Diketones from N,N'-Dimethoxy-N,N'-dimethylethanediamide. A Synthetic and Mechanistic Investigation". . p. 5016 - 5023. Retrieved 2007/10/03.
• 2、 Lempert, Karoly,Simig, Gyula,Tamas, Jozsef,Toth, Gabor. "Single-electron Transfer-initiated Thermal Reactions of Arylmethyl Halides. Part 8. The Reaction of 2-Halogeno-NN-dimethyl-2,2-diphenylacetamides with Sodium Methoxide in 2,2-Dimethoxypropane. The Effects of Added Acetone, Temperature Elevation, and of the Nature of the Halogen. Refin...". . p. 1927 - 1936. Retrieved 2007/10/02.