BOC-2-AMINO-3-METHOXYBENZOIC ACID

Base Information

• Chemical Name: BOC-2-AMINO-3-METHOXYBENZOIC ACID
• CAS No.: 1026003-01-9
• Molecular Formula: C13H17NO5
• Molecular Weight: 267.28
• Hs Code.: 2922509090
• Mol file: 1026003-01-9.mol

Synonyms:BOC-2-AMINO-3-METHOXYBENZOIC ACID

Chemical Property of BOC-2-AMINO-3-METHOXYBENZOIC ACID

Chemical Property:

• Boiling Point: 364.1±32.0 °C(Predicted)
• PKA: 3.58±0.36(Predicted)
• PSA: 84.86000
• Density: 1.243±0.06 g/cm3(Predicted)
• LogP: 2.81340

Purity/Quality:

98%min ^*data from raw suppliers

Boc-2-amino-3-methoxybenzoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC-2-AMINO-3-METHOXYBENZOIC ACID

There total 2 articles about BOC-2-AMINO-3-METHOXYBENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-3-methoxybenzoic acid (3177-80-8) + di-tert-butyl dicarbonate (24424-99-5) → 2-tert-Butoxycarbonylamino-3-methoxy-benzoic acid (1026003-01-9)

Guidance literature:

With dmap; triethylamine; In acetonitrile; at 20 ℃; for 2h;

DOI:10.1016/j.tetlet.2013.10.034

Reference yield:

carbon dioxide (124-38-9,18923-20-1) + tert-butyl 2-methoxyphenylcarbamate (154150-18-2) → 2-tert-Butoxycarbonylamino-3-methoxy-benzoic acid (1026003-01-9)

Guidance literature:

With tert.-butyl lithium; Yield given. Multistep reaction; 1.) pentane, diethyl ether, -25 deg C, 20 h, 2.) pentane, diethyl ether;

DOI:10.1021/jo9604550

Reference yield:

2-tert-Butoxycarbonylamino-3-methoxy-benzoic acid (1026003-01-9) → 3-methoxyisatoic anhydride (34954-65-9)

Guidance literature:

2-tert-Butoxycarbonylamino-3-methoxy-benzoic acid; With 2-chloro-1-methyl-pyridinium iodide; In acetonitrile; at 20 ℃; for 0.166667h;

With hydrogenchloride; In water; acetonitrile;

DOI:10.1016/j.tetlet.2013.10.034

upstream raw materials:

carbon dioxide

tert-butyl 2-methoxyphenylcarbamate

2-amino-3-methoxybenzoic acid

di-tert-butyl dicarbonate

Downstream raw materials:

3-methoxyisatoic anhydride

Refernces

• 1、 Verma, Chhaya,Sharma, Somesh,Pathak, Arunendra. "A phosgene and peroxide-free one-pot tandem synthesis of isatoic anhydrides involving anthranilic acid, boc anhydride and 2-chloro-N-methyl pyridinium iodide". supporting information. p. 6897 - 6899. Retrieved 2019/04/10.