Methyl 5α-cholestan-3β-yl ether

Base Information

• Chemical Name: Methyl 5α-cholestan-3β-yl ether
• CAS No.: 1981-90-4
• Molecular Formula: C28H50O
• Molecular Weight: 402.704
• Mol file: 1981-90-4.mol

Synonyms:Methyl 5α-cholestan-3β-yl ether

Chemical Property of Methyl 5α-cholestan-3β-yl ether

Chemical Property:

• PSA: 9.23000
• LogP: 8.12270

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 5α-cholestan-3β-yl ether

There total 26 articles about Methyl 5α-cholestan-3β-yl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3β-methoxycholest-4-ene (1981-91-5) → (5α-cholestan-3β-yl)-methyl ether (1981-90-4)

Guidance literature:

With hydrogen; ruthenium; In tert-butyl alcohol; for 1h; under 760 Torr; Ambient temperature;

DOI:10.1246/bcsj.68.3491

Reference yield: 75.0%

Cholestanol (80-97-7) + methyl iodide (74-88-4) → (5α-cholestan-3β-yl)-methyl ether (1981-90-4)

Guidance literature:

Cholestanol; With sodium hydride; In tetrahydrofuran; for 12h;

methyl iodide; In tetrahydrofuran; at 20 ℃; for 10h;

DOI:10.1246/bcsj.73.1875

Reference yield: 8.0%

O-cholestanyl thionoformate (57701-04-9) → (5α-cholestan-3β-yl)-methyl ether (1981-90-4) + 3β-cholestanyloxy methane thiol (98569-96-1)

Guidance literature:

With diphenylsilane;

DOI:10.1016/S0040-4020(01)87198-2

upstream raw materials:

diazomethane

Cholestanol

methanol

5α-cholestan-3α-yl tosylate

Downstream raw materials:

3β-phenylcholestane

Cholestanol

neocholesteryl bromide

cholestane

Refernces

• 1、 Neeman et al.. "-". . p. 36,40,41. Retrieved 1959.
• 2、 Beynon,Heilbron,Spring. "-". . p. 406,408. Retrieved 1937.
• 3、 Sakamaki, Hiroshi,Kameda, Noriyuki,Iwadare, Tsukasa,Ichinohe, Yoshiyuki. "A Novel Methylation of Allylic Alcohols Using cis-Dichlorobis(triphenylphosphine)platinum(II)-Tin(II) Chloride Dihydrate Complex Catalyst". . p. 3491 - 3496. Retrieved 2007/10/03.
• 4、 Barton, Derek H. R.,Jang, Doo Ok,Jaszberenyi, Joseph Cs.. "The invention of radical reactions. Part XXXI. Diphenylsilane: A reagent for deoxygenation of alcohols via their thiocarbonyl derivatives, deamination via isonitriles, and dehalogenation of bromo- and iodo- compounds by radical chain chemistry". . p. 7193 - 7214. Retrieved 2007/10/02.