2-(p-Chlorobenzyl)cyclohexanone

Base Information

• Chemical Name: 2-(p-Chlorobenzyl)cyclohexanone
• CAS No.: 2702-79-6
• Molecular Formula: C13H15 Cl O
• Molecular Weight: 222.7106
• Hs Code.: 2914700090
• Mol file: 2702-79-6.mol

Synonyms:Cyclohexanone,2-(p-chlorobenzyl)- (6CI,7CI,8CI); 2-(p-Chlorobenzyl)cyclohexanone

Chemical Property of 2-(p-Chlorobenzyl)cyclohexanone

Chemical Property:

• Vapor Pressure: 0.000135mmHg at 25°C
• Melting Point: 139-141 °C(Solv: ethyl acetate (141-78-6))
• Boiling Point: 333.7°Cat760mmHg
• Flash Point: 185.2°C
• PSA: 17.07000
• Density: 1.152g/cm³
• LogP: 3.64180

Purity/Quality:

2-(4-chlorobenzyl)cyclohexanone 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(p-Chlorobenzyl)cyclohexanone

There total 8 articles about 2-(p-Chlorobenzyl)cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

C14H18ClNO → 2-(4-chloro-benzyl)-cyclohexanone (2702-79-6)

Guidance literature:

With hydrogenchloride; formaldehyd; In tetrahydrofuran; at 20 ℃; for 5h;

DOI:10.1039/c5sc03903g

Reference yield:

(E)-2-(4-chlorobenzylidene)cyclohexanone (31021-05-3) → 2-(4-chloro-benzyl)-cyclohexanone (2702-79-6)

Guidance literature:

With ethanol; nickel; benzene; Hydrogenation;

DOI:10.1021/ja01587a016

Reference yield:

2-[hydroxy(4-chlorophenyl)methyl]cyclohexan-1-one (13161-16-5,13161-17-6,132556-37-7,132556-38-8,61235-09-4) → 2-(4-chloro-benzyl)-cyclohexanone (2702-79-6)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol; aqueous HCl

2: Raney nickel; benzene; ethanol / Hydrogenation

With hydrogenchloride; ethanol; nickel; benzene;

DOI:10.1021/ja01587a016

upstream raw materials:

(E)-2-(4-chlorobenzylidene)cyclohexanone

(E)-2-(4-chloro-phenylmethylene)-cyclohexanol

1-(1-Cyclohexen-1-yl)pyrrolidine

1-Chloro-4-(chloromethyl)benzene

Downstream raw materials:

3-<1-(4-Chlor-benzyl)-2-oxo-cyclohexyl>-propionsaeure

(E)-3-[7-(4-Chloro-benzyl)-2-(4-fluoro-phenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl]-propenal

7-(4-Chloro-benzyl)-2-(4-fluoro-phenyl)-4,5,6,7-tetrahydro-2H-indazole-3-carbaldehyde

2-<4-Chlor-benzyl>-2-<2-cyan-aethyl>-cyclohexanon

Refernces

• 1、 Peijnenburg, W. J. G. M.,Buck, H. M.. "THE EFFECTS OF SUBSTITUENS AND SOLVENT POLARITY ON PHOTOCHEMICAL SIGMATROPIC SHIFTS. EXPERIMENTAL EVIDENCE IN FAVOUR OF THE OCCURRENCE OF SUDDEN POLARIZATION IN ACYCLIC ALKENES". . p. 4927 - 4940. Retrieved 2007/10/02.