N-[4-(Acetyloxy)phenyl]-N-ethylacetamide

Base Information

• Chemical Name: N-[4-(Acetyloxy)phenyl]-N-ethylacetamide
• CAS No.: 529-94-2
• Molecular Formula: C₁₂H₁₅NO₃
• Molecular Weight: 221.256
• Hs Code.: 2924299090
• Mol file: 529-94-2.mol

Synonyms:N-[4-(Acetyloxy)phenyl]-N-ethylacetamide;N-Ethyl-p-hydroxyacetanilide acetate

Chemical Property of N-[4-(Acetyloxy)phenyl]-N-ethylacetamide

Chemical Property:

• PSA: 46.61000
• LogP: 1.98470

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-[4-(Acetyloxy)phenyl]-N-ethylacetamide

There total 6 articles about N-[4-(Acetyloxy)phenyl]-N-ethylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetic acid-(N-ethyl-4-hydroxy-anilide) (91457-25-9) + acetic anhydride (108-24-7) → 1-acetoxy-4-(acetyl-ethyl-amino)-benzene (529-94-2)

Guidance literature:

Reference yield:

4-acetaminophenol (103-90-2,8055-08-1) → 1-acetoxy-4-(acetyl-ethyl-amino)-benzene (529-94-2)

Guidance literature:

Multi-step reaction with 4 steps

1: NaOH-solution; alcohol

2: xylene; sodium

3: concentrated hydrochloric acid; ice water / 220 - 240 °C

With hydrogenchloride; sodium hydroxide; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethanol; sodium; xylene;

Reference yield:

4-Ethoxyaniline (156-43-4) → 1-acetoxy-4-(acetyl-ethyl-amino)-benzene (529-94-2)

Guidance literature:

Multi-step reaction with 4 steps

1: ice water

2: xylene; sodium

3: concentrated hydrochloric acid; ice water / 220 - 240 °C

With hydrogenchloride; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; sodium; xylene;

upstream raw materials:

acetic acid-(N-ethyl-4-hydroxy-anilide)

acetic anhydride

4-ethoxyacetanilide

4-acetaminophenol