7-O-ethyl-Morroniside

Base Information

• Chemical Name: 7-O-ethyl-Morroniside
• CAS No.: 945721-10-8
• Molecular Formula: C₁₉H₃₀O₁₁
• Molecular Weight: 434.441
• Mol file: 945721-10-8.mol

Synonyms:7-O-ethyl-Morroniside;(1S,3R,4aS,8S,8aS)-3-Ethoxy-8-(beta-D-glucopyranosyloxy)-4,4a,8,8a-tetrahydro-1-methyl-1H,3H-pyrano[3,4-c]pyran-5-carboxylic acid methyl ester;O-Ethylmorroniside, 7-

Chemical Property of 7-O-ethyl-Morroniside

Chemical Property:

• Boiling Point: 611.7±55.0 °C(Predicted)
• PKA: 12.80±0.70(Predicted)
• PSA: 153.37000
• Density: 1.41±0.1 g/cm3(Predicted)
• LogP: -1.38010

Purity/Quality:

99% ^*data from raw suppliers

7-O-Ethylmorroniside ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 7-O-Ethylmorroniside is a derivative of Morroniside (M725700), a pharmaceutical agent improving microvascular functional integrity and vascular elements of the neurovascular unit in the treatment of cerebral ischemia.

Technology Process of 7-O-ethyl-Morroniside

There total 3 articles about 7-O-ethyl-Morroniside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

ethanol (64-17-5) + morroniside (25406-64-8,52691-03-9,61849-88-5,61849-89-6) → 7-O-ethylmorroniside (945721-10-8)

Guidance literature:

With iodine; In acetone; at 20 ℃; for 4h;

DOI:10.1248/cpb.57.112

Reference yield: 26.0%

ethanol (64-17-5) + 7β-morroniside → 7β-O-ethylmorroniside (945721-10-8) + 7α-O-ethylmorroniside (945721-10-8)

Guidance literature:

With nitric acid; In neat (no solvent); at 20 ℃; for 0.5h;

DOI:10.3390/molecules23061412

Reference yield: 26.0%

ethanol (64-17-5) + 7β-morroniside → 7β-O-ethylmorroniside (945721-10-8) + 7α-O-ethylmorroniside (945721-10-8)

Guidance literature:

With nitric acid; In neat (no solvent); at 20 ℃; for 0.5h;

DOI:10.3390/molecules23061412

upstream raw materials:

ethanol

morroniside

Refernces

• 1、 Sunghwa, Fortunatus,Sakurai, Hiroaki,Saiki, Ikuo,Koketsu, Mamoru. "Iodine-catalyzed etherification of morroniside". experimental part. p. 112 - 115. Retrieved 2009/07/25.