2-Propylpiperidine hydrochloride

Base Information

• Chemical Name: 2-Propylpiperidine hydrochloride
• CAS No.: 51541-42-5
• Molecular Formula: C₈H₁₇N*ClH
• Molecular Weight: 163.691
• Mol file: 51541-42-5.mol

Synonyms:AKOS 220-97;2-PROPYLPIPERIDINE HCL;(+/-)-2-PROPYLPIPERIDINE HYDROCHLORIDE;2-PROPYLPIPERIDINE HYDROCHLORIDE;CONIINE, DL- HCL;DL-CICUTINE HYDROCHLORIDE;DL-CONIINE HCL;DL-CONIINE HYDROCHLORIDE

Chemical Property of 2-Propylpiperidine hydrochloride

Chemical Property:

• Vapor Pressure: 1.8mmHg at 25°C
• Melting Point: ~210 °C(lit.)
• Boiling Point: 166.2°C at 760 mmHg
• Flash Point: 48.4°C
• PSA: 12.03000
• LogP: 3.05940

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Propylpiperidine hydrochloride

There total 115 articles about 2-Propylpiperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(2R,2'S)-(+)-2-phenyl-2-(2'-propyl-piperidin-1'-yl)-ethanol (88056-96-6) → (S)-coniine hydrochloride (555-92-0,15991-59-0,51541-42-5,88057-03-8)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1016/j.tetasy.2004.01.017

Reference yield: 100.0%

benzyl (S)-2-propylpiperidine-1-carboxylate (934016-33-8) → (S)-coniine hydrochloride (555-92-0,15991-59-0,51541-42-5,88057-03-8)

Guidance literature:

With hydrogenchloride; In methanol;

Reference yield: 100.0%

(2S)-2-propyl-1-(2,3,4,6-tetra-O-pivaloyl-β-D-galactopyranosyl)piperidine (121675-94-3) → (S)-coniine hydrochloride (555-92-0,15991-59-0,51541-42-5,88057-03-8)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 36h;

DOI:10.1002/ejoc.200400169

upstream raw materials:

benzyl (S)-2-propylpiperidine-1-carboxylate

N-(benzyloxycarbonyl)-(6S)-4-(1,3-dithiolan-4-yl)-6-n-propylpiperidine

(2R)-(-)-1-((1S)-1-phenylethyl)-2-(1-prop-2-enyl)piperidine

(2S)-2-propyl-1-(2,3,4,6-tetra-O-pivaloyl-β-D-galactopyranosyl)piperidine

Refernces

• 1、 Berthold, Dino,Geissler, Arne G. A.,Giofré, Sabrina,Breit, Bernhard. "Rhodium-Catalyzed Asymmetric Intramolecular Hydroamination of Allenes". supporting information. p. 9994 - 9997. Retrieved 2019/07/04.
• 2、 Karanfil, Abdullah,Balta, Berrin,Eskici, Mustafa. "A [3+3] cyclization strategy for asymmetric synthesis of alkyl substituted piperidine-2-ones using 1,2-cyclic sulfamidates: A formal synthesis of (S)-coniine from l-norvaline". . p. 10218 - 10229,12. Retrieved 2020/09/02.