10-trans-Atorvastatin Acetonide tert-Butyl Ester

Base Information

• Chemical Name: 10-trans-Atorvastatin Acetonide tert-Butyl Ester
• CAS No.: 1105067-90-0
• Molecular Formula: C40H47FN2O5
• Molecular Weight: 654.822
• Mol file: 1105067-90-0.mol

Synonyms:10-trans-Atorvastatin Acetonide tert-Butyl Ester;(4S,6R)-6-[2-[2-(4-Fluorophenyl)-5-(1-Methylethyl)-3-phenyl-4-[(phenylaMino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-diMethyl-1,3-dioxane-4-acetic Acid 1,1-DiMethylethyl Ester

Chemical Property of 10-trans-Atorvastatin Acetonide tert-Butyl Ester

Chemical Property:

• Boiling Point: 678.0±55.0 °C(Predicted)
• PKA: 13.57±0.70(Predicted)
• PSA: 82.28000
• Density: 1.14±0.1 g/cm3(Predicted)
• LogP: 9.75300
• Storage Temp.: Refrigerator
• Solubility.: Dichloromethane

Purity/Quality:

NLT 98% ^*data from raw suppliers

10-trans-AtorvastatinAcetonidetert-ButylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 10-trans-Atorvastatin Acetonide tert-Butyl Ester

There total 1 articles about 10-trans-Atorvastatin Acetonide tert-Butyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl [(4S,6R)-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxane-4-yl]acetate (1105067-89-7) + 2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide (125971-96-2,125971-58-6) → tert-butyl (4S,6R)-6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxane-4-acetate (1105067-90-0) + tert-butyl (4R,6R)-6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxane-4-acetate (125971-95-1)

Guidance literature:

With Trimethylacetic acid; In n-heptane; toluene; for 19h; Title compound not separated from byproducts.; Heating;

DOI:10.1135/cccc20080229

upstream raw materials:

tert-butyl [(4S,6R)-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxane-4-yl]acetate

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide

Refernces