Technology Process of 2-Amino-1-pyridin-4-yl-ethanone
There total 1 articles about 2-Amino-1-pyridin-4-yl-ethanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-(bromoacetyl)pyridine;
With
hexamethylenetetramine; sodium iodide;
In
ethanol;
for 24h;
With
hydrogenchloride;
In
ethanol;
for 5h;
Reflux;
DOI:10.1016/j.bmcl.2016.03.043
- Guidance literature:
-
Multi-step reaction with 6 steps
1: sodium hydrogencarbonate / methanol / 12 h
2: hydroxylamine hydrochloride; pyridine / ethanol / 3 h
3: hydrogen; palladium 10% on activated carbon / methanol / 5 h / 2068.65 Torr
4: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h
5: hydrogenchloride / methanol / 12 h
6: sodium cyanoborohydride / methanol / 12 h
With
pyridine; hydrogenchloride; palladium 10% on activated carbon; hydroxylamine hydrochloride; hydrogen; sodium cyanoborohydride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;
In
methanol; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2016.03.043