Labetalol IMpurity A

Base Information

• Chemical Name: Labetalol IMpurity A
• CAS No.: 1391051-99-2
• Molecular Formula: C19H23NO4
• Molecular Weight: 329.39022
• Mol file: 1391051-99-2.mol

Synonyms:2-Hydroxy-5-[1-hydroxy-2-[(1-Methyl-3-phenylpropyl)aMino]ethyl]benzoic Acid;5-[1-Hydroxy-2-[(1-Methyl-3-phenylpropyl)aMino]ethyl]salicylic Acid;Labetalol IMpurity A;Labetalol-1-carboxylic Acid

Chemical Property of Labetalol IMpurity A

Chemical Property:

• Boiling Point: 565.9±50.0 °C(Predicted)
• PKA: 3.08±0.10(Predicted)
• PSA: 89.79000
• Density: 1.231±0.06 g/cm3(Predicted)
• LogP: 3.12560
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly, Heated), Methanol (Slightly, Heated)

Purity/Quality:

≥98% ^*data from raw suppliers

Labetalol1-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Labetalol-1-carboxylic Acid is an impurity of the α-and β-adrenergic, Labetalol (L096500).

Technology Process of Labetalol IMpurity A

There total 2 articles about Labetalol IMpurity A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(R,R)-Labetalol hydrochloride (75659-08-4) → C19H23NO4 (1391051-99-2)

Guidance literature:

With hydrogenchloride; In water; at 50 ℃; for 3h;

DOI:10.1021/op990185y

Reference yield: 78.0%

(R,R)-labetalol (75659-07-3) → C19H23NO4 (1391051-99-2)

Guidance literature:

With hydrogenchloride; In water; at 60 ℃; for 5h;

DOI:10.1021/op990185y

upstream raw materials:

(R,R)-Labetalol hydrochloride

(R,R)-labetalol

Refernces