SB-218078

Base Information

• Chemical Name: SB-218078
• CAS No.: 135897-06-2
• Deprecated CAS: 154624-50-7
• Molecular Formula: C24H15N3O3
• Molecular Weight: 393.401
• UNII: S6U3J3UP11
• DSSTox Substance ID: DTXSID10392024
• Nikkaji Number: J1.250.690B
• Wikidata: Q27088703
• Pharos Ligand ID: DU8HFVWYGMDM
• ChEMBL ID: CHEMBL304428
• Mol file: 135897-06-2.mol

Synonyms:SB 218078;SB-218078

Chemical Property of SB-218078

Chemical Property:

• PSA: 69.02000
• Density: 1.8g/cm³
• LogP: 4.36310
• Storage Temp.: Store at RT
• Solubility.: ≤5mg/ml in DMSO;5mg/ml in dimethyl formamide
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 393.11134135
• Heavy Atom Count: 30
• Complexity: 754

Purity/Quality:

98% ^*data from raw suppliers

SB218078 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC2N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N(C1O2)C7=C53)C(=O)NC6=O
• Description: SB 218078 is an inhibitor of checkpoint kinase 1 (Chk1) that blocks phosphorylation of cdc25 with an IC50 value of 15 nM. It less potently inhibits cdc2 and PKC (IC50s = 250 and 1,000 nM, respectively) and causes 85% inhibition of PKD1 at 1 μM. SB 218078 releases G2 cell cycle arrest induced by γ-irradiation or the topoisomerase I inhibitor topotecan . In this way, SB 218078 enhances the cytotoxicity of DNA-damaging compounds.
• Uses: SB 218078 is a selective inhibitor of Chk1.