Technology Process of 2,8-Diazaspiro[4.5]decane-2-carboxylic acid, 8-cyclobutyl-, 1,1-dimethylethyl ester
There total 4 articles about 2,8-Diazaspiro[4.5]decane-2-carboxylic acid, 8-cyclobutyl-, 1,1-dimethylethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
cyclobutanone; tert-butyl 2,8-diazaspiro[4.5]decane-2-carboxylate;
With
triethylamine;
In
dichloromethane;
at 0 ℃;
for 0.5h;
With
sodium tris(acetoxy)borohydride;
In
dichloromethane;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triethylamine / N,N-dimethyl-formamide / 20 °C
2.1: hydrogen / Pd(OH)2/C / ethanol; acetic acid / 22 h / 50 °C / 2585.81 Torr
3.1: acetic acid / dichloromethane / 0.5 h / 0 °C
3.2: 20 °C
With
hydrogen; acetic acid; triethylamine;
Pd(OH)2/C;
In
ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triethylamine / N,N-dimethyl-formamide / 20 °C
2.1: hydrogen / Pd(OH)2/C / ethanol; acetic acid / 22 h / 50 °C / 2585.81 Torr
3.1: acetic acid / dichloromethane / 0.5 h / 0 °C
3.2: 20 °C
With
hydrogen; acetic acid; triethylamine;
Pd(OH)2/C;
In
ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;