DIPHENYL-ACETIC ACID ETHYL ESTER

Base Information

• Chemical Name: DIPHENYL-ACETIC ACID ETHYL ESTER
• CAS No.: 3468-99-3
• Molecular Formula: C16H16O2
• Molecular Weight: 240.302
• Hs Code.: 2916399090
• Mol file: 3468-99-3.mol

Synonyms:Aceticacid, diphenyl-, ethyl ester (6CI,7CI,8CI);Diphenylacetic acid ethyl ester;Ethyl diphenylacetate;NSC 17496;Acetic acid, diphenyl-, ethyl ester;benzeneacetic acid, α-phenyl-, ethyl ester;Diphenyl-acetic acid ethyl ester;Ethyl diphenylacetate;

Chemical Property of DIPHENYL-ACETIC ACID ETHYL ESTER

Chemical Property:

• Vapor Pressure: 0.000109mmHg at 25°C
• Melting Point: 170-171℃
• Refractive Index: 1.553
• Boiling Point: 336.9 °C at 760 mmHg
• Flash Point: 131.2 °C
• PSA: 26.30000
• Density: 1.079 g/cm³
• LogP: 3.38160

Purity/Quality:

99% ^*data from raw suppliers

Ethyl2,2-diphenylacetate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DIPHENYL-ACETIC ACID ETHYL ESTER

There total 72 articles about DIPHENYL-ACETIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

ethanol (64-17-5) + C17H15NO3 (1045704-40-2) → dimethylenecyclourethane (497-25-6) + ethyl diphenylacetate (3468-99-3)

Guidance literature:

With samarium diiodide; In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.1055/s-2008-1072587

Reference yield: 97.0%

2-hydroxy-2-phenylacetophenone (119-53-9,579-44-2) + orthoformic acid triethyl ester (122-51-0) → ethyl diphenylacetate (3468-99-3)

Guidance literature:

With trifluorormethanesulfonic acid; In dichloromethane; at 20 ℃; for 0.25h; Reagent/catalyst; Time; Concentration; stereospecific reaction;

DOI:10.1021/ol500292c

Reference yield: 93.0%

2,2-diphenylacetic acid (117-34-0) + chloroformic acid ethyl ester (541-41-3) → ethyl diphenylacetate (3468-99-3)

Guidance literature:

With triethylamine; dmap; In dichloromethane; at 0 ℃; for 0.25h;

DOI:10.1016/S0040-4039(00)86271-1

upstream raw materials:

pyridine

chloro-diphenyl-acetaldehyde diethylacetal

diphenylacetic acid chloride

sodium ethanolate

Downstream raw materials:

N-(2-Hydroxyethyl)-2,2-diphenylacetamid

2-benzhydryl-4,5-dihydro-1H-imidazole

Ethyl-2.2-diphenyllevulinat

ethyl triphenylacetate

Refernces

• 1、 Luening, Ulrich,Petersen, Soenke,Schyja, Wolfgang,Hacker, Wolfgang,Marquardt, Torsten,Wagner, Kerstin,Bolte, Michael. "Concave pyridines for selective acylations of polyols". . p. 1077 - 1084. Retrieved 1998.
• 2、 Chen, Wenming,Chen, Guifang,Wang, Biao,Wang, Wei,Huang, Wei,Tian, Xu. "Br?nsted acid-catalyzed Friedel-Crafts-type alkylation of arenes with α-aryl diazoacetates". supporting information. . Retrieved 2021/01/25.
• 3、 Huang, Fei,Huang, He,Hughes, Timothy,Xie, Yuxing,Xu, Jun,Yu, Yang,Zhang, Zhipeng. "Catalytic C-C coupling of diazo compounds with arylboronic acids: Using surface modified sewage sludge as catalyst". supporting information. p. 4165 - 4173. Retrieved 2020/07/14.