Bosutinib Methanoate

Base Information

• Chemical Name: Bosutinib Methanoate
• CAS No.: 918639-10-8
• Molecular Formula: C27H33Cl2N5O4
• Molecular Weight: 562.48802
• Mol file: 918639-10-8.mol

Synonyms:4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile Methanoate;Bosutinib Methanoate;SKI 606 Methanoate;Bosutinib Methanoate (Discontinued see B676095)

Chemical Property of Bosutinib Methanoate

Chemical Property:

• Melting Point: 213-215°C
• PSA: 106.34000
• LogP: 4.09658
• Storage Temp.: -20°C Freezer

Purity/Quality:

98% ^*data from raw suppliers

Bosutinib methanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Bosutinib Methanoate

There total 1 articles about Bosutinib Methanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bosutinib (380843-75-4) → 4-((2,4-dichloro-5-methoxyphenyl)-amino)-6-methoxy-7-(3-(4-methyl-1-piperazinyl)-propoxy)-3-quinoline-carbonitrile methanol solvate (918639-10-8)

Guidance literature:

In methanol; at 65 ℃; for 0.5h;

Reference yield:

4-((2,4-dichloro-5-methoxyphenyl)-amino)-6-methoxy-7-(3-(4-methyl-1-piperazinyl)-propoxy)-3-quinoline-carbonitrile methanol solvate (918639-10-8) → bosutinib monohydrate (918639-08-4)

Guidance literature:

In water; at 95 ℃; for 5h; Product distribution / selectivity;

upstream raw materials:

bosutinib

Downstream raw materials:

bosutinib monohydrate

Refernces