Methyl 2-CarbaMoylbenzoate

Base Information

• Chemical Name: Methyl 2-CarbaMoylbenzoate
• CAS No.: 90564-02-6
• Molecular Formula: C9H9NO3
• Molecular Weight: 179.17266
• Hs Code.: 2924299090
• Mol file: 90564-02-6.mol

Synonyms:Methyl 2-CarbaMoylbenzoate;2-(Aminocarbonyl)benzoic acid methyl ester

Chemical Property of Methyl 2-CarbaMoylbenzoate

Chemical Property:

• PSA: 70.38000
• LogP: 1.45630
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

Methyl 2-carbamoylbenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2-CarbaMoylbenzoate

There total 9 articles about Methyl 2-CarbaMoylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N-Methoxy-phthalamic acid methyl ester → methyl 2-carbamoylbenzoate (90564-02-6)

Guidance literature:

With titanium(III) chloride; In ethanol; at 25 ℃; for 16h;

DOI:10.1021/jo00066a014

Reference yield: 78.0%

methyl 2-((tert-butoxycarbonyl)carbamoyl)benzoate → methyl 2-carbamoylbenzoate (90564-02-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1021/acs.orglett.0c03897

Reference yield:

phthalic monoacid monomethyl ester chloride (4397-55-1) → methyl 2-carbamoylbenzoate (90564-02-6)

Guidance literature:

With sulfuric acid; 1,1,1,3,3,3-hexamethyl-disilazane; Yield given. Multistep reaction; 1.) CH₂Cl₂, room temp., 2.) CH₃OH;

DOI:10.1055/s-1985-31257

upstream raw materials:

phthalic monoacid monomethyl ester chloride

methyl iodide

methanol

phthalimide

Refernces

• 1、 Khan, M. Niyaz. "Effects of CH3OH-H2O and CH3OH Solvents on Rate of Reaction of Phthalimide with Piperidine". . p. 29 - 40. Retrieved 2007/10/03.
• 2、 Pellegata, R.,Italia, A.,Villa, M.,Palmisano, G.,Lesma, G.. "A Facile Preparation of Primary Carboxamides". . p. 517 - 519. Retrieved 2007/10/02.