2-(3-CARBOXYPHENYL)PROPIONIC ACID

Base Information

• Chemical Name: 2-(3-CARBOXYPHENYL)PROPIONIC ACID
• CAS No.: 68432-95-1
• Molecular Formula: C10H10O4
• Molecular Weight: 194.187
• Hs Code.: 2918992090
• Mol file: 68432-95-1.mol

Synonyms:KETOPROFEN RELATED COMPOUND C;3-Carboxy-α-Methyl-benzeneacetic Acid (Ketoprofen IMpurity);Ketoprofen Related Compound C (20 mg) (2-(3-carboxyphenyl)propionic acid);rac-3-Carboxy-α-Methyl-benzeneacetic Acid;Ketoprofen Related CoMpound C(2-(3-carboxyphenyl)propionic acid);3-Carboxy-alpha-methylbenzeneacetic acid;DF 2008Y;3-[(1RS)-1-Carboxyethyl]benzoic acid

Chemical Property of 2-(3-CARBOXYPHENYL)PROPIONIC ACID

Chemical Property:

• Boiling Point: 393.6±25.0 °C(Predicted)
• PKA: 4.07±0.10(Predicted)
• PSA: 74.60000
• Density: 1.324±0.06 g/cm3(Predicted)
• LogP: 1.57290

Purity/Quality:

99% ^*data from raw suppliers

3-Carboxy-α-methylbenzeneaceticAcid(KetoprofenImpurity) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A impurity of Ketoprofen (K200800). 3-Carboxy-α-methylbenzeneacetic Acid (Ketoprofen EP Impurity C) is a impurity of Ketoprofen (K200800). Ketoprofen USP Compound C: (2-(3-Carboxyphenyl)propionic Acid)

Technology Process of 2-(3-CARBOXYPHENYL)PROPIONIC ACID

There total 2 articles about 2-(3-CARBOXYPHENYL)PROPIONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-(3-carboxyphenyl)propanenitrile (5537-71-3) → 2-(3-carboxyphenyl)propionic acid (68432-95-1)

Guidance literature:

With sodium hydroxide; for 5h; Heating;

Reference yield:

→ 2-(3-carboxyphenyl)propionic acid (68432-95-1)

Guidance literature:

entspr. Propionitril 5, KOH/H2O;

Reference yield: 84.03%

2-(pyridin-4-yl)-1H-benzo[d]imidazole (2208-59-5) + 2-(3-carboxyphenyl)propionic acid (68432-95-1) + cadmium sulfate hydrate → C12H9N3*C10H8O4(2-)*Cd(2+)

Guidance literature:

With sodium hydroxide; In water; at 160 ℃; for 72h; Autoclave; High pressure;

DOI:10.1016/j.poly.2016.12.008

upstream raw materials:

2-(3-carboxyphenyl)propanenitrile

Refernces

• 1、 Allegretti, Marcello,Bertini, Riccardo,Cesta, Maria Candida,Bizzarri, Cinzia,Di Bitondo, Rosa,Di Cioccio, Vito,Galliera, Emanuela,Berdini, Valerio,Topai, Alessandra,Zampella, Giuseppe,Russo, Vincenzo,Di Bello, Nicoletta,Nano, Giuseppe,Nicolini, Luca,Locati, Massimo,Fantucci, Piercarlo,Florio, Saverio,Colotta, Francesco. "2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors". . p. 4312 - 4331. Retrieved 2007/10/03.