Bis(tert-Butoxycarbonyl) LisdexaMphetaMine

Base Information

• Chemical Name: Bis(tert-Butoxycarbonyl) LisdexaMphetaMine
• CAS No.: 819871-13-1
• Molecular Formula: C25H41N3O5
• Molecular Weight: 463.618
• Mol file: 819871-13-1.mol

Synonyms:Bis(tert-Butoxycarbonyl) LisdexaMphetaMine;[(1S)-1-[[[(1S)-1-Methyl-2-phenylethyl]aMino]carbonyl]-1,5-pentanediyl]bis-carbaMic Acid Bis(1,1-diMethylethyl) Ester

Chemical Property of Bis(tert-Butoxycarbonyl) LisdexaMphetaMine

Chemical Property:

• PSA: 116.23000
• LogP: 5.57120

Purity/Quality:

97% ^*data from raw suppliers

Bis(tert-butoxycarbonyl) lisdexamphetamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Protected Lisdexamphetamine.

Technology Process of Bis(tert-Butoxycarbonyl) LisdexaMphetaMine

There total 15 articles about Bis(tert-Butoxycarbonyl) LisdexaMphetaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dexamfetamine (51-64-9,17108-96-2,96332-84-2) + Boc-Lys(Boc)-OH (2483-46-7) → [5-tert-butoxycarbonylamino-5-(1-methyl-2-phenylethylcarbamoyl)pentyl]carbamic acid tert-butyl ester (819871-13-1)

Guidance literature:

Boc-Lys(Boc)-OH; With N-ethyl-N,N-diisopropylamine; In ethyl acetate; at 20 ℃; for 0.166667h; Inert atmosphere;

dexamfetamine; With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In ethyl acetate; at 20 - 25 ℃; Cooling with ice-water bath;

Reference yield:

diboc-Lysdex-aziridine → [5-tert-butoxycarbonylamino-5-(1-methyl-2-phenylethylcarbamoyl)pentyl]carbamic acid tert-butyl ester (819871-13-1)

Guidance literature:

With palladium on activated charcoal; hydrogen; In isopropyl alcohol; for 3h; under 2068.65 Torr; Time;

Reference yield:

Boc-Lys(Boc)-OH (2483-46-7) + D-amphetamine sulfate (17279-36-6) → [5-tert-butoxycarbonylamino-5-(1-methyl-2-phenylethylcarbamoyl)pentyl]carbamic acid tert-butyl ester (819871-13-1)

Guidance literature:

Boc-Lys(Boc)-OH; With N-ethyl-N,N-diisopropylamine; In ethyl acetate; at 20 - 25 ℃; for 0.166667h;

D-amphetamine sulfate; In ethyl acetate; at 20 - 25 ℃; for 0.333333h;

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In ethyl acetate; at 20 - 25 ℃; Cooling with ice-water bath;

upstream raw materials:

dexamfetamine

Boc-Lys(Boc)-OH

D-amphetamine sulfate

di-tert-butyl dicarbonate

Downstream raw materials:

dexamfetamine

L-lysine-d-amphetamine dihydrochloride

Refernces

• 1、 -. "AMPHETAMINE CONTROLLED RELEASE, PRODRUG, AND ABUSE-DETERRENT DOSAGE FORMS". . . Retrieved 2018/09/16.
• 2、 -. "AMPHETAMINE CONTROLLED RELEASE, PRODRUG, AND ABUSE DETERRENT DOSAGE FORMS". . . Retrieved 2017/09/15.