3-Methoxy-7β-Methyl-6β-(phenylsulfonyl) Estradiol

Base Information

• Chemical Name: 3-Methoxy-7β-Methyl-6β-(phenylsulfonyl) Estradiol
• CAS No.: 156137-95-0
• Molecular Formula: C₂₆H₃₂O₄S
• Molecular Weight: 440.604
• Mol file: 156137-95-0.mol

Synonyms:(6R,7R,8R,9S,13S,14S,17S)-6-(benzenesulfonyl)-3-methoxy-7,13-dimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-ol;

Chemical Property of 3-Methoxy-7β-Methyl-6β-(phenylsulfonyl) Estradiol

Chemical Property:

• PSA: 71.98000
• LogP: 6.21150
• Solubility.: Dichloromethane, Ethyl Acetate

Purity/Quality:

98% ^*data from raw suppliers

3-Methoxy-7β-methyl-6β-(phenylsulfonyl)Estradiol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: As Estradiol derivative, 3-Methoxy-7β-Methyl-6β-(phenylsulfonyl) Estradiol can be used in the preparation of alkylated estratrienes. Estradiol derivative used in the preparation of alkylated estratrienes.

Technology Process of 3-Methoxy-7β-Methyl-6β-(phenylsulfonyl) Estradiol

There total 2 articles about 3-Methoxy-7β-Methyl-6β-(phenylsulfonyl) Estradiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyllithium (917-54-4) + 17β-acetyloxy-3-methoxy-6-(phenylsulfonyl)estra-1,3,5(10),6-tetraene (153004-08-1) → (6R,7S,8R,9S,13S,14S,17S)-6-Benzenesulfonyl-3-methoxy-7,13-dimethyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-ol (156137-95-0) + (6R,7R,8R,9S,13S,14S,17S)-6-Benzenesulfonyl-3-methoxy-7,13-dimethyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-ol (156137-95-0)

Guidance literature:

With potassium hydroxide; Product distribution; 1.) ether, THF, -78 deg C to -10 deg C; different organolithium reagents;

DOI:10.1016/0040-4039(94)88321-1

Reference yield:

methyllithium (917-54-4) + 17β-acetyloxy-3-methoxy-6-(phenylsulfonyl)estra-1,3,5(10),6-tetraene (153004-08-1) → (6R,7S,8R,9S,13S,14S,17S)-6-Benzenesulfonyl-3-methoxy-7,13-dimethyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-ol (156137-95-0) + (6R,7R,8R,9S,13S,14S,17S)-6-Benzenesulfonyl-3-methoxy-7,13-dimethyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-ol (156137-95-0)

Guidance literature:

With potassium hydroxide; Product distribution; 1.) ether, THF, -78 deg C to -10 deg C; different organolithium reagents;

DOI:10.1016/0040-4039(94)88321-1

Reference yield: 91.0%

(6R,7S,8R,9S,13S,14S,17S)-6-Benzenesulfonyl-3-methoxy-7,13-dimethyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-ol (156137-95-0) → 3-methoxy-7α-methylestra-1,3,5(10)-trien-17β-ol (15506-01-1)

Guidance literature:

With ammonia; lithium; ammonium chloride; at -50 ℃;

DOI:10.1016/0040-4039(94)88321-1

upstream raw materials:

methyllithium

17β-acetyloxy-3-methoxy-6-(phenylsulfonyl)estra-1,3,5(10),6-tetraene

Downstream raw materials:

3-methoxy-7α-methylestra-1,3,5(10)-trien-17β-ol

Refernces