N-acetic acid-1-aMino-3-adaMantanol

Base Information

• Chemical Name: N-acetic acid-1-aMino-3-adaMantanol
• CAS No.: 1032564-18-3
• Molecular Formula: C12H19NO3
• Molecular Weight: 225.288
• Mol file: 1032564-18-3.mol

Synonyms:N-acetic acid-1-aMino-3-adaMantanol;Vildagliptin Impurity 4;(3-hydroxyadamantan-1-ylamino)acetic acid

Chemical Property of N-acetic acid-1-aMino-3-adaMantanol

Chemical Property:

• Boiling Point: 399.4±27.0 °C(Predicted)
• PKA: 2.35±0.10(Predicted)
• PSA: 69.56000
• Density: 1.30±0.1 g/cm3(Predicted)
• LogP: 1.13520
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility.: DMSO (Slightly, Heated), Methanol (Slightly)

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

2-((3-Hydroxyadamantan-1-yl)amino)aceticacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-(3-Hydroxytricyclo[3.3.1.13,7]dec-1-yl)glycine, is an impurity of Vildagliptin (V305000), a class of oral anti-hyperglycemic agents that inhibit dipeptidyl peptidase 4 (DPP-4), which can act as a serine exopeptidase.

Technology Process of N-acetic acid-1-aMino-3-adaMantanol

There total 7 articles about N-acetic acid-1-aMino-3-adaMantanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.6%

3-hydroxy-1-adamantyl-glycine ethyl ester → [(3‐hydroxytricyclo[3.3.1.13,7]decan‐1‐yl)amino]acetic acid (1032564-18-3)

Guidance literature:

With ethanol; potassium hydroxide; at 65 ℃;

Reference yield: 90.0%

(3-hydroxyadamantan-1-ylamino)acetonitrile → [(3‐hydroxytricyclo[3.3.1.13,7]decan‐1‐yl)amino]acetic acid (1032564-18-3)

Guidance literature:

With water; sodium hydroxide; at 65 - 70 ℃;

Reference yield:

t-butyl 2-(3-hydroxyadamantan-1-ylamino)acetate (1334337-68-6) → [(3‐hydroxytricyclo[3.3.1.13,7]decan‐1‐yl)amino]acetic acid (1032564-18-3)

Guidance literature:

t-butyl 2-(3-hydroxyadamantan-1-ylamino)acetate; With water; potassium hydroxide; at 20 ℃; for 12h;

With hydrogenchloride; In water;

upstream raw materials:

3-aminoadamantan-1-ol

1-Adamantanamine

amantadine hydrochloride

[(3-hydroxyadamantan-1-yl)imino]acetic acid

Downstream raw materials:

vildagliptin

(S)-1-[2-(3-hydroxyadamantan-1-ylamino)acetyl]pyrrolidine-2-carboxylic acid amide

Refernces

• 1、 -. "NOVEL ECONOMIC PROCESS FOR VILDAGLIPTIN". . . Retrieved 2015/09/28.