3-(1-PYRROLIDINYL)-PIPERIDINE

Base Information

• Chemical Name: 3-(1-PYRROLIDINYL)-PIPERIDINE
• CAS No.: 144243-28-7
• Molecular Formula: C9H18N2
• Molecular Weight: 154.25
• Hs Code.: 2933990090
• Mol file: 144243-28-7.mol

Synonyms:3-(1-PYRROLIDINYL)-PIPERIDINE;3-PYRROLIDIN-1-YL-PIPERIDINE;3-(1-pyrrolidinyl)piperidine(SALTDATA: 2HCl);3-(1-Pyrrolidinyl)-piperidine 2HCl

Chemical Property of 3-(1-PYRROLIDINYL)-PIPERIDINE

Chemical Property:

• Vapor Pressure: 0.0637mmHg at 25°C
• Boiling Point: 231°C at 760 mmHg
• PKA: 10.28±0.20(Predicted)
• Flash Point: 93.8°C
• PSA: 15.27000
• Density: 0.989g/cm³
• LogP: 1.10090

Purity/Quality:

98%min ^*data from raw suppliers

3-(1-Pyrrolidinyl)-piperidineDihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(1-PYRROLIDINYL)-PIPERIDINE

There total 3 articles about 3-(1-PYRROLIDINYL)-PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(tert-butoxycarbonyl)-3-(1-pyrrolidinyl)piperidine fumarate (144243-27-6) → 3-(pyrrolidin-1-yl)piperidine (144243-28-7)

Guidance literature:

With trifluoroacetic acid; In chloroform; for 0.166667h; Ambient temperature;

DOI:10.1021/jm00101a011

Reference yield: 93.0%

3-(1H-pyrrol-1-yl)pyridine (72692-99-0) → 3-(pyrrolidin-1-yl)piperidine (144243-28-7)

Guidance literature:

3-(1H-pyrrol-1-yl)pyridine; With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In methanol; water; at 100 ℃; for 8h; under 53203.6 Torr; Autoclave;

With sodium hydrogencarbonate; In isopropyl alcohol; for 1.5h; Reflux;

DOI:10.1007/s10593-011-0890-1

Reference yield:

CF3 COOH + 1-(tert-butoxycarbonyl)-3-(1-pyrrolidinyl)piperidine (144243-26-5) → 3-(pyrrolidin-1-yl)piperidine (144243-28-7)

Guidance literature:

In sodium hydroxide; chloroform;

upstream raw materials:

1-(tert-butoxycarbonyl)-3-(1-pyrrolidinyl)piperidine fumarate

1-(tert-butoxycarbonyl)-3-(1-pyrrolidinyl)piperidine

3-(1H-pyrrol-1-yl)pyridine

Downstream raw materials:

3-(1-pyrrolidinyl)-1-<2-(3,4-dichlorophenyl)ethyl>piperidine

3-(1-pyrrolidinyl)-1-<(3,4-dichlorophenyl)acetyl>piperidine

Refernces

• 1、 -. "NITROGEN-CONTAINING CYCLOHETERO CYCLOHETEROAMINOARYL DERIVATIVES FOR CNS DISORDERS". . . Retrieved 2008/06/13.