Quizalofop-ethyl

Base Information

• Chemical Name: Quizalofop-ethyl
• CAS No.: 76578-14-8
• Molecular Formula: C19H17 Cl N2 O4
• Molecular Weight: 372.808
• Hs Code.: 2933399024
• Mol file: 76578-14-8.mol

Synonyms:Assure; DPX6202; DPX-Y 6202; DPX-Y 6202-3; Ethyl 2-[4-(6-chloro-2-quinoxalyloxy)phenoxy]propionate;Miura; NC 302; NCI 96683; Quinofop-ethyl; Quizalofop-ethyl; Targa;Xylofop-ethyl

Chemical Property of Quizalofop-ethyl

Chemical Property:

• Vapor Pressure: 3.05E-10mmHg at 25°C
• Melting Point: 91.7-92.1oC
• Refractive Index: 1.6800 (estimate)
• Boiling Point: 503.9 °C at 760 mmHg
• PKA: -1.39±0.48(Predicted)
• Flash Point: 258.6 °C
• PSA: 70.54000
• Density: 1.301 g/cm³
• LogP: 4.40590
• Storage Temp.: 0-6°C
• Water Solubility.: 303ug/L(temperature not stated)

Purity/Quality:

99% ^*data from raw suppliers

Quizalofop-ethyl ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R21/22:
• Hazard Codes: Xn
• Statements: 21/22
• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Herbicide. Quizalofop-ethyl is a selective postemergence herbicide used to control both annual and perennial grasses in soybeans and cotton.

Technology Process of Quizalofop-ethyl

There total 8 articles about Quizalofop-ethyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.9%

ethyl (S)-2-[[(4-methylphenyl)sulfonyl]oxy]propanoate (57057-80-4) + 6-chloro-2-(4-hydroxyphenoxy)quinoxaline (76578-79-5) → (R)-2-[4-[(6-chloro-2-quinoxalinyl)oxy]phenoxy]propanoic acid ethyl ester (76578-14-8,100646-51-3)

Guidance literature:

With potassium carbonate; In methyl cyclohexane; for 3h; Solvent; Inert atmosphere; Reflux;

Reference yield: 95.1%

(L) Ethyl 2-chloropropanoate (74497-15-7) + 6-chloro-2-(4-hydroxyphenoxy)quinoxaline (76578-79-5) → (R)-2-[4-[(6-chloro-2-quinoxalinyl)oxy]phenoxy]propanoic acid ethyl ester (76578-14-8,100646-51-3)

Guidance literature:

With tetrabutylammomium bromide; triethylamine; In toluene; at 60 ℃; for 4h; Solvent; Temperature; Reflux;

Reference yield: 75.0%

2,6-dichloroquinoxaline (18671-97-1) + ethanol (64-17-5) + (R)-2-(4-hydroxyphenoxy)propionic acid (94050-90-5) → (R)-2-[4-[(6-chloro-2-quinoxalinyl)oxy]phenoxy]propanoic acid ethyl ester (76578-14-8,100646-51-3)

Guidance literature:

2,6-dichloroquinoxaline; (R)-2-(4-hydroxyphenoxy)propionic acid; With potassium phosphate; tetra-(n-butyl)ammonium iodide; In N,N-dimethyl-formamide; at 50 - 60 ℃; for 2h;

With 1,3,5-trichloro-2,4,6-triazine; In N,N-dimethyl-formamide; at 5 - 25 ℃; for 1.16667h;

ethanol; In N,N-dimethyl-formamide;

DOI:10.4067/S0717-97072011000400002

upstream raw materials:

6-chloro-2-(4-hydroxyphenoxy)quinoxaline

ethyl (S)-2-[[(4-methylphenyl)sulfonyl]oxy]propanoate

2,6-dichloroquinoxaline

ethanol

Downstream raw materials:

(RS)-tetrahydrofuran-2-ylmethyl (R)-2-[4-(6-chloro-2-quinoxalinyloxy)phenoxy]propionate

quizalofop-p

Refernces

• 1、 -. "Preparation method of quizalofop-P-ethyl". Paragraph 0042; 0043; 0044; 0049-0051; 0055-0057. . Retrieved 2017/03/28.
• 2、 Clemente-Tejeda, David,Lara, Juan Carlos Ortiz,Zard, Samir Z.. "A Direct Approach to Enantiopure Propionate Derivatives from Ethyl Lactate". . p. 3393 - 3399. Retrieved 2016/09/12.