4-Desacetyl Vincristine

Base Information

• Chemical Name: 4-Desacetyl Vincristine
• CAS No.: 3704-01-6
• Molecular Formula: C45H57N4O13S
• Molecular Weight: 894.01808
• Mol file: 3704-01-6.mol

Synonyms:4-Deacetylvincristin;4-Desacetyl Vincristine;O4-Deacetyl-22-oxo-vincaleukoblastine;4-Deacetylvincristine;4-Desacetyl Vincristine Methosulfate;4-Deacetyl Leurocristine;O4-Deacetyl-22-oxo-vincaleukoblastine Methosulfate

Chemical Property of 4-Desacetyl Vincristine

Chemical Property:

• Melting Point: >300?C (dec.)
• PSA: 165.10000
• LogP: 3.52340
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Solubility.: Methanol

Purity/Quality:

99% ^*data from raw suppliers

4-DesacetylVincristineMethosulfate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A metabolite of Vincristine in bile. Antitumor agent used against human colon carcinoma. 4-Desacetyl Vincristine is a metabolite of Vincristine in bile. Antitumor agent used against human colon carcinoma.

Technology Process of 4-Desacetyl Vincristine

There total 2 articles about 4-Desacetyl Vincristine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

vincristine dihydrogen sulphate (2068-78-2,23397-21-9,132142-73-5) → 4-deacetylvincristine (3704-01-6,74741-40-5)

Guidance literature:

With phosphate buffer; In methanol; at 37 ℃; for 8h; pH 12.0;

Reference yield: 70.0%

Vincristine (57-22-7) → desacetylvincristine (3704-01-6)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; at 20 ℃; for 48h;

DOI:10.1021/bc400441s

upstream raw materials:

vincristine dihydrogen sulphate

Vincristine

Refernces

• 1、 Thimmaiah,Lloyd,Sethi. "A simple method for the chemical modification of antitumour catharanthus (Vinca) alkaloids". . p. 678 - 680. Retrieved 2007/10/02.