Technology Process of Isocoumarin, 3,4-dihydro-6,8-dihydroxy-3-(6-methyl-tetrahydro-2H-pyran-2-yl)-
There total 19 articles about Isocoumarin, 3,4-dihydro-6,8-dihydroxy-3-(6-methyl-tetrahydro-2H-pyran-2-yl)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
3,5-dihydroxyphenol; iodine; tetra-(n-butyl)ammonium iodide; aluminium;
In
benzene;
at 0 ℃;
for 0.5h;
Inert atmosphere;
DOI:10.1021/jo300805n
- Guidance literature:
-
Multi-step reaction with 5 steps
1: (1R,2R)-(-)-N,N'-bis(3,5-di-tert-butylsalicydene)-1,2-cyclohexanediaminocobalt(II); acetic acid / toluene / 1 h / 20 °C
2: copper(l) iodide / tetrahydrofuran / -30 °C
3: toluene-4-sulfonic acid / dichloromethane / 1 h
4: Jones reagent / acetone / 1 h / 0 - 20 °C
5: 3,5-dihydroxyphenol; iodine; tetra-(n-butyl)ammonium iodide; aluminium / benzene / 0.5 h / 0 °C / Inert atmosphere
With
copper(l) iodide; Jones reagent; (1R,2R)-(-)-N,N'-bis(3,5-di-tert-butylsalicydene)-1,2-cyclohexanediaminocobalt(II); 3,5-dihydroxyphenol; iodine; tetra-(n-butyl)ammonium iodide; toluene-4-sulfonic acid; acetic acid; aluminium;
In
tetrahydrofuran; dichloromethane; acetone; toluene; benzene;
3: oxa-Pictet-Spengler cyclization / 4: Jones oxidation;
DOI:10.1021/jo300805n
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 10 h / 0 - 20 °C
2: (1R,2R)-(-)-N,N'-bis(3,5-di-tert-butylsalicydene)-1,2-cyclohexanediaminocobalt(II); acetic acid / toluene / 1 h / 20 °C
3: copper(l) iodide / tetrahydrofuran / -30 °C
4: toluene-4-sulfonic acid / dichloromethane / 1 h
5: Jones reagent / acetone / 1 h / 0 - 20 °C
6: 3,5-dihydroxyphenol; iodine; tetra-(n-butyl)ammonium iodide; aluminium / benzene / 0.5 h / 0 °C / Inert atmosphere
With
copper(l) iodide; Jones reagent; (1R,2R)-(-)-N,N'-bis(3,5-di-tert-butylsalicydene)-1,2-cyclohexanediaminocobalt(II); 3,5-dihydroxyphenol; iodine; tetra-(n-butyl)ammonium iodide; toluene-4-sulfonic acid; acetic acid; 3-chloro-benzenecarboperoxoic acid; aluminium;
In
tetrahydrofuran; dichloromethane; acetone; toluene; benzene;
4: oxa-Pictet-Spengler cyclization / 5: Jones oxidation;
DOI:10.1021/jo300805n
