Methyl 4-bromo-3-formylbenzoate

Base Information

• Chemical Name: Methyl 4-bromo-3-formylbenzoate
• CAS No.: 858124-35-3
• Molecular Formula: C9H7BrO3
• Molecular Weight: 243.057
• Hs Code.: 2918300090
• Mol file: 858124-35-3.mol

Synonyms:Methyl 4-bromo-3-formylbenzoate

Chemical Property of Methyl 4-bromo-3-formylbenzoate

Chemical Property:

• Boiling Point: 336.8±27.0 °C(Predicted)
• PSA: 43.37000
• Density: 1.566±0.06 g/cm3(Predicted)
• LogP: 2.04820
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Methyl 4-bromo-3-formylbenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 4-bromo-3-formylbenzoate

There total 8 articles about Methyl 4-bromo-3-formylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methyl 4-bromo-3-(dibromomethyl)benzoate (877624-37-8) → 4-bromo-3-formyl-benzoic acid methyl ester (858124-35-3)

Guidance literature:

methyl 4-bromo-3-(dibromomethyl)benzoate; With morpholine; at 20 ℃; for 48h;

With water; citric acid;

Reference yield: 84.0%

methyl 4-bromo-3-(hydroxymethyl)benzoate (254746-40-2) → 4-bromo-3-formyl-benzoic acid methyl ester (858124-35-3)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; for 23h; Heating / reflux;

Reference yield: 79.0%

2-bromo-5-(methoxycarbonyl)phenylmethylene diacetate (1095432-84-0) → 4-bromo-3-formyl-benzoic acid methyl ester (858124-35-3)

Guidance literature:

2-bromo-5-(methoxycarbonyl)phenylmethylene diacetate; With sulfuric acid; In methanol; water; Reflux;

With hydrogenchloride; water; In tetrahydrofuran; Reflux;

DOI:10.1002/anie.200802908

upstream raw materials:

methyl 4-bromo-3-(dibromomethyl)benzoate

methyl 4-bromo-3-(hydroxymethyl)benzoate

methanol

2-bromo-5-(methoxycarbonyl)phenylmethylene diacetate

Downstream raw materials:

4-bromo-3-formyl-benzoic acid

Refernces

• 1、 Wei, Simin,Zhou, Xi-Rui,Huang, Zhentao,Yao, Qingxin,Gao, Yuan. "Hydrogen sulfide induced supramolecular self-assembly in living cells". supporting information. p. 9051 - 9054. Retrieved 2018/08/21.
• 2、 Williams, Derek E.,Dolgopolova, Ekaterina A.,Pellechia, Perry J.,Palukoshka, Andrei,Wilson, Thomas J.,Tan, Rui,Maier, Josef M.,Greytak, Andrew B.,Smith, Mark D.,Krause, Jeanette A.,Shustova, Natalia B.. "Mimic of the green fluorescent protein β-barrel: Photophysics and dynamics of confined chromophores defined by a rigid porous scaffold". . p. 2223 - 2226. Retrieved 2015/03/04.