Ethyl (S)-3-benzylpiperidine-3-carboxylate

Base Information Edit

Chemical Name:Ethyl (S)-3-benzylpiperidine-3-carboxylate
CAS No.:170844-45-8
Molecular Formula:C15H21NO2
Molecular Weight:247.33274
Hs Code.:
Mol file:170844-45-8.mol

Synonyms:3-Piperidinecarboxylic acid, 3-(phenylMethyl)-, ethyl ester,(S)-;Ethyl (S)-3-benzylpiperidine-3-carboxylate;3-Piperidinecarboxylic acid, 3-(phenylmethyl)-, ethyl ester, (3S)-

Suppliers and Price of Ethyl (S)-3-benzylpiperidine-3-carboxylate

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
3-Piperidinecarboxylicacid,3-(phenylmethyl)-,ethylester,(S)-
100mg
$ 331.00

Total 4 raw suppliers

Chemical Property of Ethyl (S)-3-benzylpiperidine-3-carboxylate Edit

Chemical Property:

PSA：38.33000
LogP:2.49080

Purity/Quality:

NLT 98% ^*data from raw suppliers

3-Piperidinecarboxylicacid,3-(phenylmethyl)-,ethylester,(S)- ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of Ethyl (S)-3-benzylpiperidine-3-carboxylate

There total 14 articles about Ethyl (S)-3-benzylpiperidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 170844-45-8,170844-43-6
(S)-3-carbethoxy-3-benzylpiperidine

Guidance literature:

Reference yield:

: 10444-15-2
diethyl 2-benzyl-2-(2-cyanoethyl)malonate

: 170844-45-8,170844-43-6
(S)-3-carbethoxy-3-benzylpiperidine

Guidance literature:: Multi-step reaction with 7 steps

1: 70 percent / H₂, aq. HCl / Pd(OH)2 / ethanol / 22 h / 50 °C / 2172.02 Torr

2: 89 percent / Et₃N / CH₂Cl₂ / 2 h / 25 °C

3: phosphate buffer, porcine liver esterase / H₂O / 27 h / 37 °C

4: TFA / CH₂Cl₂ / 1.5 h / 40 °C

5: DCC, DIEA, HOBT, DMAP / CH₂Cl₂ / 20 h / 25 °C

6: Lawesson's reagent / toluene / 2 h / 110 °C

7: 100 mg / NaBH₄, Raney Ni / tetrahydrofuran; ethanol; H₂O / 0.25 h

With Lawessons reagent; hydrogenchloride; porcine liver esterase; dmap; sodium tetrahydroborate; phosphate buffer; hydrogen; nickel; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium dihydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; toluene;
DOI:10.1021/jo980990v

Reference yield:

: 607-81-8
diethyl 2-benzylmalonate

: 170844-45-8,170844-43-6
(S)-3-carbethoxy-3-benzylpiperidine

Guidance literature:: Multi-step reaction with 8 steps

1: 99 percent / EtONa, MTBE / ethanol / 1 h / 40 °C

2: 70 percent / H₂, aq. HCl / Pd(OH)2 / ethanol / 22 h / 50 °C / 2172.02 Torr

3: 89 percent / Et₃N / CH₂Cl₂ / 2 h / 25 °C

4: phosphate buffer, porcine liver esterase / H₂O / 27 h / 37 °C

5: TFA / CH₂Cl₂ / 1.5 h / 40 °C

6: DCC, DIEA, HOBT, DMAP / CH₂Cl₂ / 20 h / 25 °C

7: Lawesson's reagent / toluene / 2 h / 110 °C

8: 100 mg / NaBH₄, Raney Ni / tetrahydrofuran; ethanol; H₂O / 0.25 h

With Lawessons reagent; hydrogenchloride; porcine liver esterase; dmap; sodium tetrahydroborate; phosphate buffer; tert-butyl methyl ether; hydrogen; sodium ethanolate; nickel; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium dihydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; toluene;
DOI:10.1021/jo980990v