INDEX NAME NOT YET ASSIGNED

Base Information

• Chemical Name: INDEX NAME NOT YET ASSIGNED
• CAS No.: 796729-10-7
• Molecular Formula: C7H8N2O2
• Molecular Weight: 152.153
• Hs Code.: 2933199090
• Mol file: 796729-10-7.mol

Synonyms:4H-Pyrrolo[1,2-b]pyrazole-3-carboxylic acid, 5,6-dihydro-

Chemical Property of INDEX NAME NOT YET ASSIGNED

Chemical Property:

• Boiling Point: 359.0±30.0 °C(Predicted)
• PKA: 3.47±0.20(Predicted)
• PSA: 55.12000
• Density: 1.55
• LogP: 0.52750
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

5,6-Dihydro-4H-pyrrolo[1,2-B]pyrazole-3-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of INDEX NAME NOT YET ASSIGNED

There total 4 articles about INDEX NAME NOT YET ASSIGNED which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-3-carboxylic acid ethyl ester (86477-10-3) → 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-3-carboxylic acid (796729-10-7)

Guidance literature:

With water; sodium hydroxide; In ethanol; at 0 - 20 ℃;

Reference yield:

methyl 5, 6-dihydro-4H-pyrrolo[1,2-b]pyrazole-3-carboxylate → 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-3-carboxylic acid (796729-10-7)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃;

Reference yield:

5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylic acid methyl ester (1454848-65-7) + methyl 5, 6-dihydro-4H-pyrrolo[1,2-b]pyrazole-3-carboxylate → 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylic acid (796729-03-8) + 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-3-carboxylic acid (796729-10-7)

Guidance literature:

With water; sodium hydroxide; In methanol; at 50 ℃; for 5h;

upstream raw materials:

5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-3-carboxylic acid ethyl ester

5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylic acid methyl ester

Downstream raw materials:

3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole

Refernces

• 1、 -. "BIARYL COMPOUNDS USEFUL FOR THE TREATMENT OF HUMAN DISEASES IN ONCOLOGY, NEUROLOGY AND IMMUNOLOGY". Paragraph 0546. . Retrieved 2015/06/25.
• 2、 -. "PYRAZOLE AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS FOR USE IN THE TREATMENT OF PARKINSON'S DISEASE". Page/Page column 51. . Retrieved 2013/11/19.