L-4-CHLOROPHENYLALANINE METHYL ESTER HCL

Base Information

• Chemical Name: L-4-CHLOROPHENYLALANINE METHYL ESTER HCL
• CAS No.: 63024-26-0
• Molecular Formula: C10H13Cl2NO2
• Molecular Weight: 265.74
• Hs Code.: 2922499990
• Mol file: 63024-26-0.mol

Synonyms:P-CHLOROPHENYLALANINE METHYLESTER HYDROCHLORIDE;METHYL 4-CHLORO-L-PHENYLALANINATE HYDROCHLORIDE;L-4-CHLOROPHENYLALANINE METHYL ESTER HCL;Methyl 4-chloro-L-phenylalaninate

Chemical Property of L-4-CHLOROPHENYLALANINE METHYL ESTER HCL

Chemical Property:

• PSA: 52.32000
• LogP: 2.88510
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

L-2-Naphthylalaninemethylesterhydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-4-CHLOROPHENYLALANINE METHYL ESTER HCL

There total 11 articles about L-4-CHLOROPHENYLALANINE METHYL ESTER HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + N-tert-butoxycarbonyl-3-(2-naphthyl)-L-alanine (56583-58-5,76985-10-9,58438-04-3) → methyl (S)-2-amino-3-(naphthalen-2-yl)propanoate hydrochloride (63024-26-0)

Guidance literature:

With thionyl chloride; at 50 ℃; for 5h; Inert atmosphere;

DOI:10.1002/anie.201913563

Reference yield: 99.0%

methanol (67-56-1) + L-3-(2-naphthyl)alanine (6960-34-5,14108-60-2,58438-03-2,76985-09-6,106107-92-0) → methyl (S)-2-amino-3-(naphthalen-2-yl)propanoate hydrochloride (63024-26-0)

Guidance literature:

With acetyl chloride; at 0 ℃; for 18h; Reflux;

DOI:10.1021/acs.orglett.8b03551

Reference yield: 95.0%

methanol (67-56-1) + L-3-(naphthalen-2-yl)alanine hydrochloride → methyl (S)-2-amino-3-(naphthalen-2-yl)propanoate hydrochloride (63024-26-0)

Guidance literature:

With thionyl chloride; for 2h; Heating;

DOI:10.1016/S0957-4166(00)80371-7

upstream raw materials:

methanol

L-3-(2-naphthyl)alanine

acetylamino-[2]naphthylmethyl-malonic acid diethyl ester

(S)-N-acetyl-3-(2-naphthyl)alanine

Refernces

• 1、 Shao, Duanyang,Zhang, Guo-Ning,Niu, Weixiao,Li, Ziqiang,Zhu, Mei,Wang, Juxian,Li, Donghui,Wang, Yucheng. "Design, Synthesis, and Cytotoxic Activity of 3-Aryl-N-hydroxy-2-(sulfonamido)propanamides in HepG2, HT-1080, KB, and MCF-7 Cells". . . Retrieved 2019/04/03.
• 2、 Amer, Mostafa M.,Carrasco, Ana C.,Leonard, Daniel J.,Ward, John W.,Clayden, Jonathan. "Substituted Dihydroisoquinolinones by Iodide-Promoted Cyclocarbonylation of Aromatic α-Amino Acids". supporting information. p. 7977 - 7981. Retrieved 2019/01/04.