quinolin-6-yl acetate

Base Information

• Chemical Name: quinolin-6-yl acetate
• CAS No.: 24306-33-0
• Molecular Formula: C11H9NO2
• Molecular Weight: 187
• Hs Code.: 2933499090
• Mol file: 24306-33-0.mol

Synonyms:quinolin-6-yl acetate;6-acetoxy-quinoline

Chemical Property of quinolin-6-yl acetate

Chemical Property:

• PSA: 39.19000
• LogP: 2.16010
• Storage Temp.: 2-8°C

Purity/Quality:

98% purity ^*data from raw suppliers

Quinolin-6-ylacetate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of quinolin-6-yl acetate

There total 4 articles about quinolin-6-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

6-hydroxyquinoline (580-16-5) + acetyl chloride (75-36-5) → methyl quinolin-6-ylethanoate (24306-33-0)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield:

4-amino-phenol (123-30-8) → methyl quinolin-6-ylethanoate (24306-33-0)

Guidance literature:

Multi-step reaction with 2 steps

1: glycerol; concentrated sulfuric acid; hydrochloric acid

2: sodium acetate

With hydrogenchloride; sulfuric acid; sodium acetate; glycerol;

Reference yield:

6-hydroxyquinoline (580-16-5) + acetic anhydride (108-24-7) → methyl quinolin-6-ylethanoate (24306-33-0)

Guidance literature:

With sodium acetate;

upstream raw materials:

6-hydroxyquinoline

acetic anhydride

acetyl chloride

4-amino-phenol

Downstream raw materials:

3-iodo-6-hydroxyquinoline

3-bromo-6-methoxyquinoline

4-(6-(benzyloxy)quinolin-3-yl)-3-methylmorpholine

3-aminoquinolin-6-ol

Refernces

• 1、 Verma, Vishal A.,Wang, Lan,Labadie, Sharada S.,Liang, Jun,Sellers, Benjamin D.,Wang, Jian,Dong, Liting,Wang, Qiuyue,Zhang, Shuang,Xu, Zhongya,Zhang, Yexia,Niu, Yanan,Wang, Xinxin,Wai, John,Koehler, Michael F. T.,Hu, Huiyong,Alexander, Mary Kate,Nishiyama, Mireille,Miu, Anh,Xu, Yiming,Pang, Jodie,Katakam, Anand K.,Reichelt, Michael,Austin, Cary D.,Ho, Hoangdung,Payandeh, Jian,Koth, Christopher M.. "Discovery of Inhibitors of the Lipopolysaccharide Transporter MsbA: From a Screening Hit to Potent Wild-Type Gram-Negative Activity". supporting information. p. 4085 - 4120. Retrieved 2022/03/02.
• 2、 -. "SUBSTITUTED 1,5-NAPHTHYRIDINES OR QUINOLINES AS ALK5 INHIBITORS". Paragraph 410; 411. . Retrieved 2021/05/29.