2-HYDROXY-4-IODO-BENZALDEHYDE

Base Information

• Chemical Name: 2-HYDROXY-4-IODO-BENZALDEHYDE
• CAS No.: 38170-02-4
• Molecular Formula: C7H5IO2
• Molecular Weight: 248.02
• Hs Code.: 2913000090
• DSSTox Substance ID: DTXSID10593014
• Nikkaji Number: J1.259.153E
• Wikidata: Q82487389
• Mol file: 38170-02-4.mol

Synonyms:2-HYDROXY-4-IODO-BENZALDEHYDE;BENZALDEHYDE, 2-HYDROXY-4-IODO-

Chemical Property of 2-HYDROXY-4-IODO-BENZALDEHYDE

Chemical Property:

• Melting Point: 87 °C
• Boiling Point: 290.0±30.0 °C(Predicted)
• PKA: 7.32±0.10(Predicted)
• PSA: 37.30000
• Density: 2.039±0.06 g/cm3(Predicted)
• LogP: 1.80930
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 247.93343
• Heavy Atom Count: 10
• Complexity: 127

Purity/Quality:

98%min ^*data from raw suppliers

BENZALDEHYDE,2-HYDROXY-4-IODO- 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1I)O)C=O
• Uses: 2-hydroxy-4-iodobenzaldehyde is used in the preparation of anti-B7-H3 antibodies.

Technology Process of 2-HYDROXY-4-IODO-BENZALDEHYDE

There total 11 articles about 2-HYDROXY-4-IODO-BENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-Iodophenol (533-58-4) → 4-iodosalicylaldehyde (38170-02-4)

Guidance literature:

With triethylamine; magnesium chloride; In acetonitrile; at 10 - 72 ℃; for 2h;

Reference yield: 79.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 3-Iodophenol (626-02-8) → 4-iodosalicylaldehyde (38170-02-4)

Guidance literature:

With triethylamine; magnesium chloride; In acetonitrile; at 10 - 72 ℃; for 2h;

DOI:10.1016/j.bmcl.2010.07.054

Reference yield: 14.0%

chloroform (67-66-3,8013-54-5) + 3-Iodophenol (626-02-8) → 4-iodosalicylaldehyde (38170-02-4)

Guidance literature:

With sodium hydroxide; In water; at 70 ℃;

DOI:10.1246/bcsj.73.417

upstream raw materials:

chloroform

3-Iodophenol

Bromoform

formaldehyd

Downstream raw materials:

2-hydroxy-4-iodo-5-nitrobenzaldehyde

(2,4-dichloro-phenyl)-(6-iodo-benzofuran-2-yl)-methanone

C₂₄H₁₄O₄

C₂₃H₁₃NO₄

Refernces

• 1、 Niu, Yahui,Wang, Qin,Wu, Haoran,Wang, Yuxiu,Zhang, Yanrong. "Experimental and DFT studies of disubstituted 2-(2-hydroxyphenyl)benzothiazole-based fluorophores synthesized by Suzuki coupling". . p. 9796 - 9805. Retrieved 2017.
• 2、 -. "Coumarin oxime ester photoinitiator". Paragraph 0095-0101. . Retrieved 2019/10/02.