Ethyl naphtho[2,1-d]thiazole-2-carboxylate

Base Information

• Chemical Name: Ethyl naphtho[2,1-d]thiazole-2-carboxylate
• CAS No.: 68557-39-1
• Molecular Formula: C14H11NO2S
• Molecular Weight: 257.30764
• Hs Code.: 2934999090
• Mol file: 68557-39-1.mol

Synonyms:Ethyl naphtho[2,1-d]thiazole-2-carboxylate

Chemical Property of Ethyl naphtho[2,1-d]thiazole-2-carboxylate

Chemical Property:

• Melting Point: 131-133 °C
• Boiling Point: 413.9±28.0 °C(Predicted)
• PKA: -1.93±0.30(Predicted)
• PSA: 67.43000
• Density: 1.321±0.06 g/cm3(Predicted)
• LogP: 3.62620
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

Ethylnaphtho[2,1-d]thiazole-2-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl naphtho[2,1-d]thiazole-2-carboxylate

There total 5 articles about Ethyl naphtho[2,1-d]thiazole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

2-Amino-1-thiocyanatonaphthalene (2476-69-9) + oxalic acid diethyl ester (95-92-1) → ethyl naphtho[2,1-d]thiazole-2-carboxylate (68557-39-1)

Guidance literature:

2-Amino-1-thiocyanatonaphthalene; With sodium sulfide trihydrate; In ethanol; water; Heating;

oxalic acid diethyl ester; at 175 ℃;

DOI:10.1134/S0036023621020054

Reference yield:

naphthalen-2-ylamine (91-59-8) → ethyl naphtho[2,1-d]thiazole-2-carboxylate (68557-39-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: bromine / methanol / 0.5 h / -78 - 20 °C

2.1: sodium sulfide trihydrate / water; ethanol / Heating

2.2: 175 °C

With sodium sulfide trihydrate; bromine; In methanol; ethanol; water;

DOI:10.1134/S0036023621020054

Reference yield:

ethyl acetoacetate (141-97-9) + 2-p-tolylazo-naphthalene-1-sulfenyl bromide (68557-37-9) → ethyl naphtho[2,1-d]thiazole-2-carboxylate (68557-39-1)

Guidance literature:

In ethanol; for 144h; Ambient temperature;

upstream raw materials:

ethyl acetoacetate

2-p-tolylazo-naphthalene-1-sulfenyl bromide

2-phenylazo-naphthalene-1-sulfenyl bromide

ethyl 2-cyanoacetate

Refernces