2',3',5'-TRI-O-ACETYL-2N,2N-DIMETHYL-GUANOSINE

Base Information

• Chemical Name: 2',3',5'-TRI-O-ACETYL-2N,2N-DIMETHYL-GUANOSINE
• CAS No.: 73196-87-9
• Molecular Formula: C18H23N5O8
• Molecular Weight: 437.40392
• Mol file: 73196-87-9.mol

Synonyms:2',3',5'-TRI-O-ACETYL-2N,2N-DIMETHYL-GUANOSINE;N,N-DiMethyl-guanosine 2',3',5'-Triacetate

Chemical Property of 2',3',5'-TRI-O-ACETYL-2N,2N-DIMETHYL-GUANOSINE

Chemical Property:

• PSA: 155.20000
• LogP: -0.07820
• Storage Temp.: Refrigerator
• Solubility.: Chloroform, Dichloromethane, DMSO, Methanol

Purity/Quality:

97% ^*data from raw suppliers

2’,3’,5’-Tri-O-acetyl-2N,2N-dimethylGuanosine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2’,3’,5’-Tri-O-acetyl-2N,2N-dimethyl Guanosine (cas# 73196-87-9) is a compound useful in organic synthesis.

Technology Process of 2',3',5'-TRI-O-ACETYL-2N,2N-DIMETHYL-GUANOSINE

There total 5 articles about 2',3',5'-TRI-O-ACETYL-2N,2N-DIMETHYL-GUANOSINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2',3',5'-tri-O-acetyl-guanosine (6979-94-8) → 2′,3′,5′-tri-O-acetyl-N2,N2-dimethylguanosine (73196-87-9)

Guidance literature:

With sodium cyanoborohydride; In acetic acid; at 40 ℃; for 32h;

DOI:10.1021/jo952263v

Reference yield: 95.0%

2',3',5'-Tri-O-acetyl-N2-methyl-N2-<(p-tolylthio)methyl>guanosine (73196-86-8) → 2′,3′,5′-tri-O-acetyl-N2,N2-dimethylguanosine (73196-87-9)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; for 3h; Heating;

DOI:10.1021/jo00003a052

Reference yield: 94.0%

2',3',5'-Tri-O-acetyl-N2-(1,3-benzodithiol-2-yl)-N2-methylguanosine (130469-18-0) → 2′,3′,5′-tri-O-acetyl-N2,N2-dimethylguanosine (73196-87-9)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; for 1h; Heating;

DOI:10.1021/jo00003a052

upstream raw materials:

2',3',5'-Tri-O-acetyl-N²-methyl-N²-<(p-tolylthio)methyl>guanosine

2',3',5'-Tri-O-acetyl-N²-(1,3-benzodithiol-2-yl)-N²-methylguanosine

2',3',5'-tri-O-(tert-butyldimethylsilyl)guanosine

formaldehyd

Downstream raw materials:

N₂,N₂-dimethylguanosine

N,N-dimethylguanosine 5'-phosphate

Refernces

• 1、 Sekine,Satoh. "A convenient method for the synthesis of N2,N2-dimethylguanosine by reductive C-S bond cleavage with tributyltin hydride". . p. 1224 - 1227. Retrieved 2007/10/02.