S(-)-SCH-23388 DES-CHLORO- HCL

Base Information

• Chemical Name: S(-)-SCH-23388 DES-CHLORO- HCL
• CAS No.: 109010-52-8
• Molecular Formula: C₁₇H₁₉NO
• Molecular Weight: 253.344
• Mol file: 109010-52-8.mol

Synonyms:S(-)-SCH-23388 DES-CHLORO- HCL

Chemical Property of S(-)-SCH-23388 DES-CHLORO- HCL

Chemical Property:

• PSA: 23.47000
• LogP: 3.75190
• Solubility.: H2O: soluble

Purity/Quality:

98%Min ^*data from raw suppliers

S(?)-SCH-23388, Des-chloro hydrochloride analytical standard ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of S(-)-SCH-23388 DES-CHLORO- HCL

There total 2 articles about S(-)-SCH-23388 DES-CHLORO- HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

8-Methoxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine → [125I]-SKF 83692 (109010-52-8)

Guidance literature:

With hydrogen bromide; Reflux;

DOI:10.1016/j.ejmech.2014.07.059

Reference yield:

→ (R)-7-hydroxy-3-methyl-8-nitro-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine + [125I]-Sch 23982 (128053-58-7,109010-52-8)

Guidance literature:

Reference yield: 85.5%

trifluoromethylsulfonic anhydride (358-23-6) + [125I]-SKF 83692 (109010-52-8) → 3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl trifluoromethanesulfonate (1564256-51-4)

Guidance literature:

[125I]-SKF 83692; With triethylamine; In dichloromethane; at -78 ℃; for 0.5h;

trifluoromethylsulfonic anhydride; In dichloromethane;

DOI:10.1021/ml400373j

Downstream raw materials:

3-methyl-5-phenyl-2,3,4,5-tetrahydro-benzo[d]azepin-7-amine

2-((5-chloro-2-((3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide

3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl trifluoromethanesulfonate

Refernces

• 1、 -. "Novel benzazepine derivatives". . . Retrieved 2008/06/13.