4-Pyridin-4-yl-1,3-dihydro-imidazole-2-thione hydrochloride

Base Information

• Chemical Name: 4-Pyridin-4-yl-1,3-dihydro-imidazole-2-thione hydrochloride
• CAS No.: 167897-35-0
• Molecular Formula: C₈H₇N₃S*ClH
• Molecular Weight: 213.691
• Mol file: 167897-35-0.mol

Synonyms:4-Pyridin-4-yl-1,3-dihydro-imidazole-2-thione hydrochloride

Chemical Property of 4-Pyridin-4-yl-1,3-dihydro-imidazole-2-thione hydrochloride

Chemical Property:

• PSA: 80.37000
• LogP: 2.56240

Purity/Quality:

99%min ^*data from raw suppliers

4-PYRIDIN-4-YL-1,3-DIHYDRO-IMIDAZOLE-2-THIONE HYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Pyridin-4-yl-1,3-dihydro-imidazole-2-thione hydrochloride

There total 2 articles about 4-Pyridin-4-yl-1,3-dihydro-imidazole-2-thione hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

potassium thioacyanate (333-20-0) + 4-(α-aminoacetyl)pyridine dihydrochloride (73286-33-6,75140-35-1,51746-83-9) → 4-(4-pyridyl)imidazole-2-thione hydrochloride (167897-35-0)

Guidance literature:

In water; at 90 ℃; for 4h;

DOI:10.1021/jm00017a018

Reference yield:

2-(4-pyridyl)-2,2-dimethoxyethylamine dihydrochloride (167897-36-1) → 4-(4-pyridyl)imidazole-2-thione hydrochloride (167897-35-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / conc. HCl / methanol / 4 h / 50 °C

2: 70 percent / H₂O / 4 h / 90 °C

With hydrogenchloride; In methanol; water;

DOI:10.1021/jm00017a018

Reference yield: 44.0%

4-(4-pyridyl)imidazole-2-thione hydrochloride (167897-35-0) → 4-(1H-imidazol-4-yl)pyridine (51746-87-3)

Guidance literature:

With nickel; In ethanol; for 6h; Heating;

DOI:10.1021/jm00017a018

upstream raw materials:

potassium thioacyanate

4-(α-aminoacetyl)pyridine dihydrochloride

2-(4-pyridyl)-2,2-dimethoxyethylamine dihydrochloride

Downstream raw materials:

4-(1H-imidazol-4-yl)pyridine

Refernces