1-(BENZYLOXY)-3-CHLOROPROPANE

Base Information

• Chemical Name: 1-(BENZYLOXY)-3-CHLOROPROPANE
• CAS No.: 26420-79-1
• Molecular Formula: C10H13ClO
• Molecular Weight: 184.666
• Hs Code.: 2909309090
• Mol file: 26420-79-1.mol

Synonyms:Ether,benzyl 3-chloropropyl (6CI,8CI);1-Benzyloxy-3-chloropropane;1-Chloro-3-benzyloxypropane;3-Benzyloxy-1-chloropropane;3-Chloro-1-benzyloxypropane;Benzyl 3-chloropropyl ether;NSC 6169;

Chemical Property of 1-(BENZYLOXY)-3-CHLOROPROPANE

Chemical Property:

• Vapor Pressure: 0.0351mmHg at 25°C
• Refractive Index: 1.509
• Boiling Point: 250 °C at 760 mmHg
• Flash Point: 109.9 °C
• PSA: 9.23000
• Density: 1.067 g/cm³
• LogP: 2.83210
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

3-Chloropropoxymethylbenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(BENZYLOXY)-3-CHLOROPROPANE

There total 11 articles about 1-(BENZYLOXY)-3-CHLOROPROPANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

benzyl mesylate (55791-06-5) + 1-chloro-3-hydroxypropane (627-30-5) → 1-chloro-3-benzyloxypropane (26420-79-1)

Guidance literature:

With magnesium oxide; lithium trifluoromethanesulfonate; lithium tetrakis(pentafluorophenyl)borate; In dichloromethane; cyclohexane; at 20 ℃; for 24h;

DOI:10.1246/cl.2000.1352

Reference yield: 97.0%

benzyl chloride (100-44-7) + 1-chloro-3-hydroxypropane (627-30-5) → 1-chloro-3-benzyloxypropane (26420-79-1)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; for 1.5h; Ambient temperature;

DOI:10.1246/bcsj.65.1932

Reference yield: 95.0%

1-chloro-3-hydroxypropane (627-30-5) + benzyl alcohol (100-51-6,185532-71-2) → 1-chloro-3-benzyloxypropane (26420-79-1)

Guidance literature:

With [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold (I); at 150 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

DOI:10.1002/adsc.201401097

upstream raw materials:

3-benzyloxypropan-1-ol

benzyl bromide

1-chloro-3-hydroxypropane

benzyl chloride

Downstream raw materials:

6-benzyloxy-2-methylhexene

benzyl hexyl ether

4-benzyloxy-1-(furan-3'-yl)butan-1-one

1-(furan-3'-yl)-2-phenylethan-1-one

Refernces

• 1、 Targel, Tom A.,Kumar, Jayprakash N.,Shneider, O. Svetlana,Bar, Sukanta,Fridman, Natalia,Maximenko, Shimon,Szpilman, Alex M.. "Oxidative asymmetric umpolung alkylation of Evans' β-ketoimides using dialkylzinc nucleophiles". supporting information. p. 2546 - 2549. Retrieved 2015/04/14.
• 2、 -. "A METHOD OF MANUFACTURING (-)-L-(3-HYDROXYPROPYL)-5-[(2R)-2-({2,2,2-TRIFLUOROETHOXY)- PHENOXYETHYL}AMINO)PROPYL]-2,3-DIHYDRO-LH-INDOLE-7-CARBOXAMIDE". Page/Page column 28. . Retrieved 2012/05/31.