6-Amino-N-hydroxy-3-pyridinecarboximidamide

Base Information

• Chemical Name: 6-Amino-N-hydroxy-3-pyridinecarboximidamide
• CAS No.: 468068-28-2
• Molecular Formula: C6H8N4O
• Molecular Weight: 152.156
• Hs Code.: 2933399090
• Mol file: 468068-28-2.mol

Synonyms:6-Amino-N-hydroxy-3-pyridinecarboximidamide;6-Aminonicotinamide oxime, 97%;6-Aminonicotinamidoxime, 97%;5-(2-Aminopyridyl)amide oxime;6-Amino-N-hydroxynicotinamidine;6-Aminopyridine-3-amidoxime

Chemical Property of 6-Amino-N-hydroxy-3-pyridinecarboximidamide

Chemical Property:

• Melting Point: 192-195℃
• Boiling Point: 426.036oC at 760 mmHg
• Flash Point: 211.459oC
• PSA: 95.02000
• Density: 1.51g/cm3
• LogP: 1.03980

Purity/Quality:

NLT 98% ^*data from raw suppliers

6-Aminopyridine-3-amidoxime 95% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 25-37/38-41
• Safety Statements: 26-39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Amino-N-hydroxy-3-pyridinecarboximidamide

There total 1 articles about 6-Amino-N-hydroxy-3-pyridinecarboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

6-aminonicotinonitrile (4214-73-7) → 6-amino-N'-hydroxy-3-pyridinecarboximidamide (468068-28-2) + 6-aminonicotinic amide (329-89-5)

Guidance literature:

With hydroxylamine hydrochloride; sodium carbonate; In ethanol; water; for 6h; Heating / reflux;

Reference yield:

6-amino-N'-hydroxypyridine-3-carboximidamide (468068-28-2) + 1-(2-fluorophenyl)-5-(methoxymethyl)-1H-1,2,3-triazole-4-carboxylic acid (1166831-65-7) → 5-{5-[1-(2-fluorophenyl)-5-(methoxymethyl)-1H-1,2,3-triazol-4-yl]-1,2,4-oxadiazol-3-yl}pyridin-2-amine (1166830-43-8)

Guidance literature:

6-amino-N'-hydroxypyridine-3-carboximidamide; 1-(2-fluorophenyl)-5-(methoxymethyl)-1H-1,2,3-triazole-4-carboxylic acid; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 20 ℃; for 18h; Microwave irradiation;

With pyridine; In acetonitrile; at 150 ℃; for 0.25h; Microwave irradiation;

Reference yield:

6-amino-N'-hydroxypyridine-3-carboximidamide (468068-28-2) + ethyl 1-(2-fluorophenyl)-5-pyridin-4-yl-1H-1,2,3-triazole-4-carboxylate (1166831-73-7) → 5-{5-[1-(2-fluorophenyl)-5-pyridin-4-yl-1H-1,2,3-triazol-4-yl]-1,2,4-oxadiazol-3-yl}pyridin-2-amine (1166830-34-7)

Guidance literature:

With potassium carbonate; In toluene; acetonitrile; at 180 ℃; for 0.5h; Microwave irradiation;

upstream raw materials:

6-aminonicotinonitrile

Downstream raw materials:

5-{5-[1-(2-fluorophenyl)-5-(methoxymethyl)-1H-1,2,3-triazol-4-yl]-1,2,4-oxadiazol-3-yl}pyridin-2-amine

5-{5-[1-(2-fluorophenyl)-5-pyridin-4-yl-1H-1,2,3-triazol-4-yl]-1,2,4-oxadiazol-3-yl}pyridin-2-amine

Refernces